Case report: lymphatic malformation
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Abstract
Lymphatic malformation is a congenital disease caused by hamartoma malformation of the lymphatic system, affecting the skin and subcutaneous tissue. Lymphangiomas typically occur before the age of 5 and are caused by improper connections of the lymphatic ducts to the main lymphatic drainage channels. A 3-day-old female patient was examined on October 13, 2023, at the NICU of Regional General Hospital K.R.M.T. Wongsonegoro (RSWN) with complaints of lumps on two parts of the body. The patient was admitted with complaints of lumps in two areas of the body, the left neck area, and the left armpit area. Laboratory results indicated decreased CRP, hypocalcemia, hyponatremia, decreased urea, decreased creatinine, anemia, decreased erythrocyte count, and hypoalbuminemia. Lymphangioma is a rare benign congenital disorder of the lymphatic system that usually presents in childhood. Lymphangiomas result from congenital or acquired abnormalities of the lymphatic system. In this patient, the lumps were on the left side of the neck and in the left axillary region. The patient was also jaundiced for 3 days after hospitalization. The patient was delivered by caesarean section due to placenta previa. At the time of additional diagnosis, the patient had neonatal pneumonia, neonatal infection, neonatal hyperbilirubinemia, hypokalemia, sepsis, moderate asphyxia, and moderate respiratory distress. Early diagnosis, intensive monitoring, and appropriate intervention for lymphatic malformations are needed to minimize the increased risk of complications. Further research is needed to evaluate the complications of lymphatic malformations and their treatment.
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References
Atqiaee, K., Samady Khanghah, A., Mohajerzadeh, L., Mardi, A., Khayat Zahiri, F., & Barin, S. (2023). Dumble cystic lymphangioma as an underlying cause of vague abdominal complaints in a 2-year-old girl: case report. Annals of Medicine & Surgery, 85(8). https://doi.org/10.1097/ms9.0000000000000395
Bekdemir, Ş., Gündüz, A. K., & Ataoğlu, Ö. (2020). Ipsilateral Lymphatic and Venous Malformations Affecting the Midface Area. Case Reports in Ophthalmological Medicine, 2020. https://doi.org/10.1155/2020/2845035
Chandra, S. R., Kumar, J., & Nair, S. C. (2022). Medical Management of Vascular Lesions: Current and the Future. In Management of Head and Neck Vascular Lesions: A Guide for Surgeons. https://doi.org/10.1007/978-981-15-2321-2_5
Goss, J. A., Zamakhshary, M., Langer, J. C., & Christison-Lagay, E. (2023). Lymphatic Malformations BT - Pediatric Surgery: Diagnosis and Management (P. Puri & M. E. Höllwarth (eds.); pp. 609–623). Springer International Publishing. https://doi.org/10.1007/978-3-030-81488-5_47
Hassan, H., & Aly, K. A. (2012). Management of cystic lymphangioma: experience of two referral centers. Annals of Pediatric Surgery, 8(4), 123–128. https://doi.org/10.1097/01.XPS.0000418462.68421.e3
Hyvönen, H., Salminen, P., & Kyrklund, K. (2022). Long-term outcomes of lymphatic malformations in children: An 11-year experience from a tertiary referral center. Journal of Pediatric Surgery, 57(12). https://doi.org/10.1016/j.jpedsurg.2022.07.024
Jeong, J., Tanaka, M., & Iwakiri, Y. (2022). Hepatic lymphatic vascular system in health and disease. In Journal of Hepatology (Vol. 77, Issue 1). https://doi.org/10.1016/j.jhep.2022.01.025
Khanwalkar, A., Valika, T., & Maddalozzo, J. (2020). Long-term symptom control following resection of cervical lymphatic malformations: A case series. Journal of Otolaryngology - Head and Neck Surgery, 49(1). https://doi.org/10.1186/s40463-020-00415-8
Kulungowski, A. M., & Patel, M. (2020). Lymphatic malformations. Seminars in Pediatric Surgery, 29(5), 150971. https://doi.org/https://doi.org/10.1016/j.sempedsurg.2020.150971
Kurumety, S., Morris, M., & Aydi, Z. B. (2022). New-onset axillary lymphangioma: a case report. Journal of Medical Case Reports, 16(1), 242. https://doi.org/10.1186/s13256-022-03461-0
Lee, S. Y., Loll, E. G., Hassan, A. E. S., Cheng, M., Wang, A., & Farmer, D. L. (2022). Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy. In Journal of Developmental Biology (Vol. 10, Issue 1). https://doi.org/10.3390/jdb10010011
Leong, S. P., & Witte, M. H. (2022). Lymphangiogenesis: Lymphatic System and Lymph Nodes; Cancer Lymphangiogenesis and Metastasis. In Cancer Metastasis Through the Lymphovascular System. https://doi.org/10.1007/978-3-030-93084-4_21
Lin, E. Y., Rao, L., & Wang, X. H. (2023). Detection of superficial lymphatic malformation with dermoscopy and reflectance confocal microscopy. In Skin Research and Technology (Vol. 29, Issue 2). https://doi.org/10.1111/srt.13283
Magold, A. I., & Swartz, M. A. (2022). Pathogenic Exploitation of Lymphatic Vessels. In Cells (Vol. 11, Issue 6). https://doi.org/10.3390/cells11060979
Martin-Almedina, S., Mortimer, P. S., & Ostergaard, P. (2021). Development and physiological functions of the lymphatic system: Insights fromhuman genetic studies of primary lymphedema. In Physiological Reviews (Vol. 101, Issue 4). https://doi.org/10.1152/physrev.00006.2020
Miceli, A., & Stewart, K. M. (2023). Lymphangioma. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK470333/
Mirza, B., Ijaz, L., Saleem, M., Sharif, M., & Sheikh, A. (2010). Cystic hygroma: an overview. Journal of Cutaneous and Aesthetic Surgery, 3(3), 139–144. https://doi.org/10.4103/0974-2077.74488
Oliver, G., Kipnis, J., Randolph, G. J., & Harvey, N. L. (2020). The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease. In Cell (Vol. 182, Issue 2). https://doi.org/10.1016/j.cell.2020.06.039
Ozdowski, L., & Gupta, V. (2020). Physiology, Lymphatic System. In StatPearls.
Petrova, T. V., & Koh, G. Y. (2020). Biological functions of lymphatic vessels. Science, 369(6500). https://doi.org/10.1126/science.aax4063
Seyi-Olajide, J. O., Caouette-Laberge, L., Ameh, E. A., & Laberge, J.-M. (2020). Lymphangiomas BT - Pediatric Surgery: A Comprehensive Textbook for Africa (E. A. Ameh, S. W. Bickler, K. Lakhoo, B. C. Nwomeh, & D. Poenaru (eds.); pp. 1177–1194). Springer International Publishing. https://doi.org/10.1007/978-3-030-41724-6_111
Sheng, L., Yu, Z., Li, S., Cao, W., & Jiang, Z. (2021). Bleomycin sclerotherapy for large diffuse microcystic lymphatic malformations. Gland Surgery, 10(6). https://doi.org/10.21037/gs-21-70
Siggins, M. K., & Sriskandan, S. (2022). Bacterial lymphatic metastasis in infection and immunity. In Cells (Vol. 11, Issue 1). https://doi.org/10.3390/cells11010033
Sunkari, K. R., & Sunduru, P. (2020). Lymphatic System: A Path for Drug Delivery. International Journal of Advances in Pharmacy and Biotechnology, 6(2). https://doi.org/10.38111/ijapb.20200602003
Taheri, A., Bremmell, K. E., Joyce, P., & Prestidge, C. A. (2023). Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication. In Journal of Controlled Release (Vol. 363). https://doi.org/10.1016/j.jconrel.2023.10.002
Wolff, K., Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., & Leffell, D. J. (2008). Fitzpatrick’s dermatology in general medicine. McGraw-Hill New York. http://sutlib2.sut.ac.th/sut_contents/H120199_v1-2.pdf