Giant juvenile fibroadenoma mammae case report
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Abstract
Mammae fibroadenoma (FAM) is a benign breast tumor with a mass consisting of epithelial tissue and stroma located under the skin of the breast. Fibroadenomas are mostly experienced in young women aged 10-18 years. The cause is not yet known for sure, but it is suspected that an increase in hormones occurs at a young age. FAM which is rapidly enlarged in size with a tumor diameter of more than 5 cm and weighs more than 500 grams is called Giant Juvenile Fibroadenoma. Characteristics of Giant Juvenile Fibroadenoma Mammae, although it is a benign tumor, can compress the surrounding tissue and change the structure of the lobules due to its increase in size and vascularization, and is at risk of leading to malignancy indicators. The case report reported one case in an 11-year-old girl with a major complaint of a lump in the left breast, rapidly enlarging over the past 6 months before being admitted to hospital. Preoperative cytology using Fine Needle Aspiration (FNA) showed the presence of Giant Juvenile Fibroadenoma (GJF) Mammae. The patient was given wide excision surgery with a surgical margin of 1 cm followed by a mastectomy procedure. A tumor measuring 7 x 7 cm was obtained with hypervascularization. Histopathological reports show benign juvenile giant fibroadenoma mammaries with negative margins. At follow-up up to 6 months, there were no signs of recurrence on physical examination and ultrasonography.
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How to Cite
Abidin, Z. (2024) “Giant juvenile fibroadenoma mammae case report ”, Science Midwifery, 12(3), pp. 1082-1090. doi: 10.35335/midwifery.v12i3.1570.
References
Arikunto. (2019). Metodelogi Penelitian, Suatu Pengantar Pendidikan. In Rineka Cipta, Jakarta.
Baral, S., Gyawali, M., Thapa, N., Chhetri, R. K., & Dahal, P. (2020). Giant juvenile fibroadenoma in an adolescent female: A case report. Clinical Case Reports, 8(12). https://doi.org/10.1002/ccr3.3466
Bardisi, Ekhlas S; Smeets, Ann; Floris, G., Ongeval, Chantal Van; Keupers3, M., & Nevelsteen, I. (2021). A giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief Literature review. Journal of Clinical Images and Medical Case Reports, 2, 1–4.
Cáceres Fonseca, D. A., Ochoa Vásconez, J. L., Laverde Ortiz, R. J., Villavicencio Haro, K. G., & Auqui Carangui, D. A. (2022). Giant fibroadenoma of the breast, case report and literature review. Salud, Ciencia y Tecnologia, 2. https://doi.org/10.56294/saludcyt202287
Cheng, L., Tariq, H., Yan, L., Reddy, S. B., & Gattuso, P. (2023). Fine-needle aspiration of intramammary lymph nodes: a clinical, radiographic, and cytologic review. Journal of the American Society of Cytopathology, 12(1). https://doi.org/10.1016/j.jasc.2022.09.004
ÇİTGEZ, B., BARAN, E., YİĞİT, B., BAŞ, S., TUFAN, A. E., & ÖZŞAHİN, H. (2020). Breast conservation with batwing mastopexy for the management of giant juvenile fibroadenoma: A case report of a 12-year-old girl. Archives of Clinical and Experimental Medicine, 5(3). https://doi.org/10.25000/acem.799406
Dasgupta, R., Rajak, T. K., Kaushal, S., & Ritolia, N. (2022). Giant juvenile fibroadenoma of the breast in a 12-year-old girl. African Journal of Paediatric Surgery, 19(4). https://doi.org/10.4103/ajps.ajps_75_21
Dayal, S., Shukla, K. M., & Singh, A. (2017). Giant Juvenile Fibroadenoma of the Breast in a Preadolescent Girl. Pediatric Oncall, 14(1). https://doi.org/10.7199/ped.oncall.2017.1
Du, F., Dong, R., Zeng, A., Liu, Z., Yu, N., Wang, X., & Zhu, L. (2020). Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience. Journal of Surgical Oncology, 121(3). https://doi.org/10.1002/jso.25828
Dzikrullah, F.A., & Iskandar, H. (2022). A 23 Years Old Woman With Fibroadenoma Mammae: Case Report. Continuing Medical Education Fakultas Kedokteran Universitas Muhammadiyah Surakarta, 781–785.
Dzikrullah, F. A., & Iskandar, H. (2022). Perempuan Usia 23 Tahun dengan Fibroadenoma Mammae : Laporan Kasus. Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta.
Eleftheriades, A., Tsarna, E., Toutoudaki, K., Paschalidou, E., Christopoulos, N., Georgopoulos, I., Mitropoulou, G., & Christopoulos, P. (2023). Giant Juvenile Fibroadenoma: Case Report and Review of the Literature. In Journal of Clinical Medicine (Vol. 12, Issue 5). https://doi.org/10.3390/jcm12051855
Gaonkar, V. B., Mathur, S., Hussain, S., Priyadarshini, A., Sharma, C. K., Mehrotra, R., Kataria, K., Ranjan, P., Dhar, A., Seenu, V., Hari, S., & Srivastava, A. (2023). Estrogen and Progesterone Receptors in Fibroadenoma in Response to Centchroman — a Selective Oestrogen Receptor Modulator (SERM). Indian Journal of Surgery, 85(3). https://doi.org/10.1007/s12262-022-03496-z
Islam, S., Saroop, S., Bheem, V., & Naraynsingh, V. (2019). Largest giant juvenile fibroadenoma of the breast. BMJ Case Reports, 12(1). https://doi.org/10.1136/bcr-2018-227277
Johnny A, P. S. (2023). Juvenile Giant Fibroadenoma Vs. Phyllodes Tumor: Know the Difference in a 14-Years-Old Woman: Case Report. International Journal of Surgery & Surgical Techniques, 7(1). https://doi.org/10.23880/ijsst-16000174
Juarez, A. M., Juarez, C. A. S., Martinez, I. M. A., & Mondragon, E. R. (2021). Breast-conserving surgery in giant juvenile fibroadenoma: a case report. AME Surgical Journal, 1. https://doi.org/10.21037/asj-21-10
Kar, P., & Arora, J. (2023). When Friend Becomes Foe: Complications of Fibroadenoma Imaging Spectrum. Indographics, 02(01). https://doi.org/10.1055/s-0043-1771196
Kitazawa, M., Futamura, M., Tokumaru, Y., Kohyama, K., Nakakami, A., & Yoshida, K. (2022). Breast reconstruction using a tissue expander after enucleation of a giant fibroadenoma: A case report. International Journal of Surgery Case Reports, 90. https://doi.org/10.1016/j.ijscr.2021.106723
Kumar, H., Rahman, N., Ramesh, R., & Raghunandan, G. (2019). Adding bit of esthetics with science modification of batwing mastopexy for breast conservation in a young patient with giant fibroadenoma breast. Journal of Cancer Research and Therapeutics, 15(5). https://doi.org/10.4103/jcrt.JCRT_818_17
Kumar, N. (2021). Breast fibroadenoma and its clinical perspectives: a prospective observational study. International Surgery Journal, 8(7). https://doi.org/10.18203/2349-2902.isj20212720
Lima, M. R. de, Teixeira, C. M. do E., Barreto, G. P., & Leite Filho, J. G. T. de M. (2023). FIBROADENOMA AND PHYLOID TUMOR: CLINICAL DIFFERENCES AND IN IMAGING EXAMINATIONS. https://doi.org/10.29289/259453942022v32s1034
Moukit, M., Rahmoune, M., Allilou, I., & Babahabib, A. (2024). Giant juvenile fibroadenoma of the breast: a case report. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(3). https://doi.org/10.18203/2320-1770.ijrcog20240491
Mulia, I. G. B. L. P., Dewi, I. G. A. S. M., & Sumadi, I. W. J. (2021). KARAKTERISTIK KLINIKOPATOLOGI PASIEN FIBROADENOMA MAMMAE DI RSUP SANGLAH DENPASAR TAHUN 2017-2018. E-Jurnal Medika Udayana, 10(4). https://doi.org/10.24843/mu.2021.v10.i4.p12
O.J. Uchendu, U. Umeaku, M.O. Ajagha, & E. Ejuvwevwo. (2024). Giant juvenile fibroadenoma in a 15-year-old Nigerian female: A case report with review of literature. Ibom Medical Journal, 17(1). https://doi.org/10.61386/imj.v17i1.395
Pepe, F., Pisapia, P., Russo, G., Nacchio, M., Vigliar, E., Giuliano, M., Malapelle, U., Troncone, G., & Bellevicine, C. (2021). Fine-Needle Aspiration Is Suitable for Breast Cancer BRCA Molecular Assessment: A Case Report. Journal of Molecular Pathology, 2(4). https://doi.org/10.3390/jmp2040028
Sánchez González, M. J., Crespo Naranjo, J. A., & Vivas Flores, C. I. (2022). Giant juvenile fibroadenoma and reconstruction surgery: A case report and literature review. Revista de Senologia y Patologia Mamaria, 35(4). https://doi.org/10.1016/j.senol.2021.06.004
Sirigere, N., C.D, M., & Pavitra, P. (2021). AYURVEDIC MANAGEMENT OF STANAGRANTHI W.S.R TO FIBROADENOMA OF BREAST- A SINGLE CASE STUDY. International Ayurvedic Medical Journal, 9(7). https://doi.org/10.46607/iamj4309072021
Sosin, M., Pulcrano, M., Feldman, E. D., Patel, K. M., Nahabedian, M. Y., Weissler, J. M., & Rodriguez, E. D. (2015). Giant juvenile fibroadenoma: a systematic review with diagnostic and treatment recommendations. Gland Surgery, 4(4). https://doi.org/10.3978/j.issn.2227-684X.2015.06.04
Sudula, M., Tejaswi, M., Tazeen, N., & Fathima, T. (2022). MED 12 gene mutation in a case of bilateral giant juvenile fibroadenoma. Indian Journal of Pathology and Oncology, 9(4). https://doi.org/10.18231/j.ijpo.2022.082
Sugiyono. (2019). Metode Penelitian Kuantitatif, Kualitatif, dan R&D (1st ed.). Penerbit Alfabeta.
Sukmawati, E. (2018). wahyunita yulia sari, indah sulistyoningrum. Farmakologi Kebidanan. Trans Info Media (TIM).
Sukmawati, E. (2019). PENGARUH MORINGA OLEIFERA TERHADAP PENINGKATAN ASI PADA IBU MENYUSUI. JIKA, 4.
Sukmawati, E., Arief Rantauni, D., Sya, Y., Khomsah, B., Fatonah, U., Prodi DIII Kebidanan, D., & Serulingmas, S. (2023). Pelatihan Pijat Oketani Untuk Melancarkan ASI Ibu Menyusui Pada Kader Kesehatan. Jurnal Abdimas Bina Bangsa, 4(1), 506–514. https://doi.org/10.46306/jabb.v4i1
Sukmawati, E., Imanah, N. D. N., & Suwariyah, P. (2021). Pengaruh Pendampingan Kader Kesehatan terhadap Keberhasilan Menyusui untuk Memberikan ASI Eksklusif. Jurnal Kebidanan Indonesia, 12(2).
Sukmawati, E., Wijaya, M., & Hilmanto, D. (2024). Participatory Health Cadre Model to Improve Exclusive Breastfeeding Coverage with King’s Conceptual System. Journal of Multidisciplinary Healthcare, 17, 1857–1875. https://doi.org/10.2147/JMDH.S450634
Varma, K., Tripathi, S., Sharma, N., & Misra, V. (2023). Myoid hamartoma of breast clinically masquadering as phyllodes tumor- A rare case report. Indian Journal of Pathology and Oncology, 10(1). https://doi.org/10.18231/j.ijpo.2023.020
Wang, S., Xu, W., Qin, G., Wen, C., Zeng, H., He, Z., Xu, Z., & Chen, W. (2019). Differential diagnosis of phyllodes tumor and fibroadenoma of breast using mammography and ultrasonography. Chinese Journal of Medical Imaging Technology, 35(3). https://doi.org/10.13929/j.1003-3289.201809005
Zeeshan, S., Shaikh, K., Tariq, M. U., & Vohra, L. M. (2021). Giant Juvenile Fibroadenoma of the breast in a 13-year-old Pakistani girl with excellent cosmetic outcome after subareolar enucleation – A case report. International Journal of Surgery Case Reports, 79. https://doi.org/10.1016/j.ijscr.2021.01.094
Zhang, Y., Huang, J., Zhou, L., & Leng, Y. (2023). The largest and heaviest giant juvenile fibroadenoma of the breast in the Chinese population: A case report. Medicine (United States), 102(13). https://doi.org/10.1097/MD.0000000000033422
Zulkarnain, S. P. N., & Harahap, R. S. (2023). Gambaran Klinis Pasien Fibroadenoma Mammae Terkait Obesitas. Jurnal Ilmiah Maksitek, 8(1).
Baral, S., Gyawali, M., Thapa, N., Chhetri, R. K., & Dahal, P. (2020). Giant juvenile fibroadenoma in an adolescent female: A case report. Clinical Case Reports, 8(12). https://doi.org/10.1002/ccr3.3466
Bardisi, Ekhlas S; Smeets, Ann; Floris, G., Ongeval, Chantal Van; Keupers3, M., & Nevelsteen, I. (2021). A giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief Literature review. Journal of Clinical Images and Medical Case Reports, 2, 1–4.
Cáceres Fonseca, D. A., Ochoa Vásconez, J. L., Laverde Ortiz, R. J., Villavicencio Haro, K. G., & Auqui Carangui, D. A. (2022). Giant fibroadenoma of the breast, case report and literature review. Salud, Ciencia y Tecnologia, 2. https://doi.org/10.56294/saludcyt202287
Cheng, L., Tariq, H., Yan, L., Reddy, S. B., & Gattuso, P. (2023). Fine-needle aspiration of intramammary lymph nodes: a clinical, radiographic, and cytologic review. Journal of the American Society of Cytopathology, 12(1). https://doi.org/10.1016/j.jasc.2022.09.004
ÇİTGEZ, B., BARAN, E., YİĞİT, B., BAŞ, S., TUFAN, A. E., & ÖZŞAHİN, H. (2020). Breast conservation with batwing mastopexy for the management of giant juvenile fibroadenoma: A case report of a 12-year-old girl. Archives of Clinical and Experimental Medicine, 5(3). https://doi.org/10.25000/acem.799406
Dasgupta, R., Rajak, T. K., Kaushal, S., & Ritolia, N. (2022). Giant juvenile fibroadenoma of the breast in a 12-year-old girl. African Journal of Paediatric Surgery, 19(4). https://doi.org/10.4103/ajps.ajps_75_21
Dayal, S., Shukla, K. M., & Singh, A. (2017). Giant Juvenile Fibroadenoma of the Breast in a Preadolescent Girl. Pediatric Oncall, 14(1). https://doi.org/10.7199/ped.oncall.2017.1
Du, F., Dong, R., Zeng, A., Liu, Z., Yu, N., Wang, X., & Zhu, L. (2020). Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience. Journal of Surgical Oncology, 121(3). https://doi.org/10.1002/jso.25828
Dzikrullah, F.A., & Iskandar, H. (2022). A 23 Years Old Woman With Fibroadenoma Mammae: Case Report. Continuing Medical Education Fakultas Kedokteran Universitas Muhammadiyah Surakarta, 781–785.
Dzikrullah, F. A., & Iskandar, H. (2022). Perempuan Usia 23 Tahun dengan Fibroadenoma Mammae : Laporan Kasus. Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta.
Eleftheriades, A., Tsarna, E., Toutoudaki, K., Paschalidou, E., Christopoulos, N., Georgopoulos, I., Mitropoulou, G., & Christopoulos, P. (2023). Giant Juvenile Fibroadenoma: Case Report and Review of the Literature. In Journal of Clinical Medicine (Vol. 12, Issue 5). https://doi.org/10.3390/jcm12051855
Gaonkar, V. B., Mathur, S., Hussain, S., Priyadarshini, A., Sharma, C. K., Mehrotra, R., Kataria, K., Ranjan, P., Dhar, A., Seenu, V., Hari, S., & Srivastava, A. (2023). Estrogen and Progesterone Receptors in Fibroadenoma in Response to Centchroman — a Selective Oestrogen Receptor Modulator (SERM). Indian Journal of Surgery, 85(3). https://doi.org/10.1007/s12262-022-03496-z
Islam, S., Saroop, S., Bheem, V., & Naraynsingh, V. (2019). Largest giant juvenile fibroadenoma of the breast. BMJ Case Reports, 12(1). https://doi.org/10.1136/bcr-2018-227277
Johnny A, P. S. (2023). Juvenile Giant Fibroadenoma Vs. Phyllodes Tumor: Know the Difference in a 14-Years-Old Woman: Case Report. International Journal of Surgery & Surgical Techniques, 7(1). https://doi.org/10.23880/ijsst-16000174
Juarez, A. M., Juarez, C. A. S., Martinez, I. M. A., & Mondragon, E. R. (2021). Breast-conserving surgery in giant juvenile fibroadenoma: a case report. AME Surgical Journal, 1. https://doi.org/10.21037/asj-21-10
Kar, P., & Arora, J. (2023). When Friend Becomes Foe: Complications of Fibroadenoma Imaging Spectrum. Indographics, 02(01). https://doi.org/10.1055/s-0043-1771196
Kitazawa, M., Futamura, M., Tokumaru, Y., Kohyama, K., Nakakami, A., & Yoshida, K. (2022). Breast reconstruction using a tissue expander after enucleation of a giant fibroadenoma: A case report. International Journal of Surgery Case Reports, 90. https://doi.org/10.1016/j.ijscr.2021.106723
Kumar, H., Rahman, N., Ramesh, R., & Raghunandan, G. (2019). Adding bit of esthetics with science modification of batwing mastopexy for breast conservation in a young patient with giant fibroadenoma breast. Journal of Cancer Research and Therapeutics, 15(5). https://doi.org/10.4103/jcrt.JCRT_818_17
Kumar, N. (2021). Breast fibroadenoma and its clinical perspectives: a prospective observational study. International Surgery Journal, 8(7). https://doi.org/10.18203/2349-2902.isj20212720
Lima, M. R. de, Teixeira, C. M. do E., Barreto, G. P., & Leite Filho, J. G. T. de M. (2023). FIBROADENOMA AND PHYLOID TUMOR: CLINICAL DIFFERENCES AND IN IMAGING EXAMINATIONS. https://doi.org/10.29289/259453942022v32s1034
Moukit, M., Rahmoune, M., Allilou, I., & Babahabib, A. (2024). Giant juvenile fibroadenoma of the breast: a case report. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(3). https://doi.org/10.18203/2320-1770.ijrcog20240491
Mulia, I. G. B. L. P., Dewi, I. G. A. S. M., & Sumadi, I. W. J. (2021). KARAKTERISTIK KLINIKOPATOLOGI PASIEN FIBROADENOMA MAMMAE DI RSUP SANGLAH DENPASAR TAHUN 2017-2018. E-Jurnal Medika Udayana, 10(4). https://doi.org/10.24843/mu.2021.v10.i4.p12
O.J. Uchendu, U. Umeaku, M.O. Ajagha, & E. Ejuvwevwo. (2024). Giant juvenile fibroadenoma in a 15-year-old Nigerian female: A case report with review of literature. Ibom Medical Journal, 17(1). https://doi.org/10.61386/imj.v17i1.395
Pepe, F., Pisapia, P., Russo, G., Nacchio, M., Vigliar, E., Giuliano, M., Malapelle, U., Troncone, G., & Bellevicine, C. (2021). Fine-Needle Aspiration Is Suitable for Breast Cancer BRCA Molecular Assessment: A Case Report. Journal of Molecular Pathology, 2(4). https://doi.org/10.3390/jmp2040028
Sánchez González, M. J., Crespo Naranjo, J. A., & Vivas Flores, C. I. (2022). Giant juvenile fibroadenoma and reconstruction surgery: A case report and literature review. Revista de Senologia y Patologia Mamaria, 35(4). https://doi.org/10.1016/j.senol.2021.06.004
Sirigere, N., C.D, M., & Pavitra, P. (2021). AYURVEDIC MANAGEMENT OF STANAGRANTHI W.S.R TO FIBROADENOMA OF BREAST- A SINGLE CASE STUDY. International Ayurvedic Medical Journal, 9(7). https://doi.org/10.46607/iamj4309072021
Sosin, M., Pulcrano, M., Feldman, E. D., Patel, K. M., Nahabedian, M. Y., Weissler, J. M., & Rodriguez, E. D. (2015). Giant juvenile fibroadenoma: a systematic review with diagnostic and treatment recommendations. Gland Surgery, 4(4). https://doi.org/10.3978/j.issn.2227-684X.2015.06.04
Sudula, M., Tejaswi, M., Tazeen, N., & Fathima, T. (2022). MED 12 gene mutation in a case of bilateral giant juvenile fibroadenoma. Indian Journal of Pathology and Oncology, 9(4). https://doi.org/10.18231/j.ijpo.2022.082
Sugiyono. (2019). Metode Penelitian Kuantitatif, Kualitatif, dan R&D (1st ed.). Penerbit Alfabeta.
Sukmawati, E. (2018). wahyunita yulia sari, indah sulistyoningrum. Farmakologi Kebidanan. Trans Info Media (TIM).
Sukmawati, E. (2019). PENGARUH MORINGA OLEIFERA TERHADAP PENINGKATAN ASI PADA IBU MENYUSUI. JIKA, 4.
Sukmawati, E., Arief Rantauni, D., Sya, Y., Khomsah, B., Fatonah, U., Prodi DIII Kebidanan, D., & Serulingmas, S. (2023). Pelatihan Pijat Oketani Untuk Melancarkan ASI Ibu Menyusui Pada Kader Kesehatan. Jurnal Abdimas Bina Bangsa, 4(1), 506–514. https://doi.org/10.46306/jabb.v4i1
Sukmawati, E., Imanah, N. D. N., & Suwariyah, P. (2021). Pengaruh Pendampingan Kader Kesehatan terhadap Keberhasilan Menyusui untuk Memberikan ASI Eksklusif. Jurnal Kebidanan Indonesia, 12(2).
Sukmawati, E., Wijaya, M., & Hilmanto, D. (2024). Participatory Health Cadre Model to Improve Exclusive Breastfeeding Coverage with King’s Conceptual System. Journal of Multidisciplinary Healthcare, 17, 1857–1875. https://doi.org/10.2147/JMDH.S450634
Varma, K., Tripathi, S., Sharma, N., & Misra, V. (2023). Myoid hamartoma of breast clinically masquadering as phyllodes tumor- A rare case report. Indian Journal of Pathology and Oncology, 10(1). https://doi.org/10.18231/j.ijpo.2023.020
Wang, S., Xu, W., Qin, G., Wen, C., Zeng, H., He, Z., Xu, Z., & Chen, W. (2019). Differential diagnosis of phyllodes tumor and fibroadenoma of breast using mammography and ultrasonography. Chinese Journal of Medical Imaging Technology, 35(3). https://doi.org/10.13929/j.1003-3289.201809005
Zeeshan, S., Shaikh, K., Tariq, M. U., & Vohra, L. M. (2021). Giant Juvenile Fibroadenoma of the breast in a 13-year-old Pakistani girl with excellent cosmetic outcome after subareolar enucleation – A case report. International Journal of Surgery Case Reports, 79. https://doi.org/10.1016/j.ijscr.2021.01.094
Zhang, Y., Huang, J., Zhou, L., & Leng, Y. (2023). The largest and heaviest giant juvenile fibroadenoma of the breast in the Chinese population: A case report. Medicine (United States), 102(13). https://doi.org/10.1097/MD.0000000000033422
Zulkarnain, S. P. N., & Harahap, R. S. (2023). Gambaran Klinis Pasien Fibroadenoma Mammae Terkait Obesitas. Jurnal Ilmiah Maksitek, 8(1).