Potential of Inflammatory Biomarkers as Diagnostic Tools for Paediatric Inflammatory Multisystemic Syndrome related to SARS-CoV-2: Literature Review
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Sep 17, 2022
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Abstract
The World Health Organization has named the enveloped RNA virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clinical aspects and pathogenic mechanisms between hyperinflammatory disease and SARS-CoV-2 are triggering factor for the out brake of autoinflammation disease and autoimmune dysregulation. This condition is known as Paediatric Inflammatory Multisystem Syndrome Temporally (PIMS-TS) related to SARS-CoV-2 or Multisystem Inflammatory Syndrome in Children (MIS-C) related to COVID-19. There are similarities between MIS-C and other diseases, that is overlapping clinical manifestations that lead to delaying diagnosis. Therefore, whether inflammatory biomarkers could be used to distinguish between these conditions are needed to be investigated. In orderd to distinguish MIS-C from infection and other inflammatory condition, it will continue to be a challenge as the COVID-19 pandemic. Therefore, a study is needed to investigate whether inflammatory biomarkers could be used to distinguish between these conditions.
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How to Cite
Hutagaol, N. M. and Ivan Santiago (2022) “Potential of Inflammatory Biomarkers as Diagnostic Tools for Paediatric Inflammatory Multisystemic Syndrome related to SARS-CoV-2: Literature Review”, Science Midwifery, 10(4), pp. 2518-2527. doi: 10.35335/midwifery.v10i4.703.
References
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[39] Venkataraman A, Kumar NP, Hanna LE, Putlibai S, Karthick M, Rajamanikam A, et al. Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India. EBioMedicine [Internet]. 2021;66:103317. Available from: https://doi.org/10.1016/j.ebiom.2021.103317
[2] Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A. Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020;12(3).
[3] Telaumbauna D. Tinjauan Yuridis Penetapan Kedaruratan Kesehatan Masyarakat Akibat Covid-19. J Educ Dev. 2020;8(2):30–6.
[4] Kementerian Kesehatan Republik Indonesia, 2020. Pedoman Kesiapsiagaan Menghadapi Corona Virus Disease (Covid-19)
[5] World Health Organization (WHO).2020. Risk communication and community engagement readiness and initial response for novel coronaviruses (nCoV). https://www.who.int/publications- detail/risk-communication-and- community- engagement -readiness- and-initial-response-for- novel- coronaviruses-(-ncov)
[6] Patel NA. Pediatric COVID-19: Systematic review of the literature. Am J Otolaryngol - Head Neck Med Surg [Internet]. 2020;41(5):102573. Available from: https://doi.org/10.1016/j.amjoto.2020.102573
[7] Wei, M., Yuan, J., Liu, Y., Fu, T., Yu, X.,& Zhang, Z.-J. (2020). NovelCoronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. JAMA, 323(13), 1313–1314. https://doi.org/10.1001/jama.2020.2131
[8] Wu, Z., & McGoogan, J. M. (2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72.314 Cases From the Chinese Center for Disease Control and Prevention. JAMA, 323(13), 1239–1242. https://doi.org/10.1001/jama.2020.2648
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[12] Chen, Z., Zhang, Y., Simsek, M., & Kantarci, B. (2020). Deep Belief Network-based Fake Task Mitigation for Mobile Crowdsensing under Data Scarcity. ICC 2020 - 2020 IEEE International Conference on Communications (ICC), 1–7. https://doi.org/10.1109/ICC40277.2020.9148817
[13] Ji, L.-N., Chao, S., Wang, Y.-J., Li, X.-J., Mu, X.-D., Lin, M.-G., & Jiang, R.-M. (2020). Clinical features of pediatric patients with COVID-19: a report of two family cluster cases. World Journal of Pediatrics, 1–4.
[14] Hong, H., Wang, Y., Chung, H.-T., & Chen, C.-J. (2020). Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children. Pediatrics & Neonatology, 61(2),131–132.
[15] Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z., & Tong, S. (2020). Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics.
[16] Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P (2020) Hyperinflammatory shock in children during COVID- 19 pandemic. Lancet 395:1607–1608. https://doi.org/10. 1016/S0140-6736(20)31094-1.
[17] Chacon-Cruz E. Multisystem Inflammatory Syndrome in Children associated with COVID-19: Report of four cases in Mexico across the Mexico-US Border. J Infect Dis Case Reports. 2020;2020(October):1–3.
[18] Dewi R, Kaswandani N, Karyanti MR, Setyanto DB, Pudjiadi AH, Hendarto A, et al. Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia. Int J Infect Dis [Internet]. 2021;107(May 2020):78–85. Available from: https://doi.org/10.1016/j.ijid.2021.04.019
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[20] Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, Bonanomi E, D'Antiga L (2020) An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 395:1771– 1778. https://doi.org/10.1016/S0140-6736(20)31103- X
[21] Elizabeth W, Alasdair B, Julia K. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 JAMA. 2020;324(3):259-269. doi:10.1001/jama.2020.10369
Mubbasheer A, Shailesh A, Axel M, Sarah Z, John M, Kevin C, Sebastian A, Rija N, Finn BM, Fiona B, Aina T, Matthew P, Mary E, Ansel H, Karthik R, Sunil A, Alvaro M. Multisystem inflammatory syndrome in children: A systematic review Lancet.2020;September 04 doi: https://doi.org/10.1016/j.eclinm.2020.100527.
[22] Mary BF,Kevin F.et.al. MD. COVID-19: Multisystem inflammatory syndrome in children (MIS-C) clinical features, evaluation, and diagnosis UpToDate. 2021; May
[23] Centres for Disease Control and Prevention. For Parents: Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID. Available from URL: https://www.cdc.gov/mis/mis-c.html. Accessed June 27, 2021
[24] Simpson JM, Newburger JW. Multisystem Inflammatory Syndrome in Children in Association with COVID-19. Circulation. 2020;142(5):437–40
[25] Centres for Disease Control and Prevention. Kawasaki Disease. Available from URL: https://www.cdc.gov/kawasaki/index.html. Accessed June 27, 2021
[26] Laura FG, Ana IG, Fernanda SAP, Karina MP, Patrícia H. Kawasaki and COVID-19 disease in children: a systematic review. Revista da Associação Médica Brasileira. 2020. doi : https://doi.org/10.1590/1806-9282.66.S2.136
[27] Zahra B, Mathilde M, Fanny B, Diala K, Antoine L, Samya A, Johanne A, Marion G, Mehdi O, Maurice B, Julie W, Caroline O, Sebastien H, Maëlle S, Sophie MM, Alice M, Gilles B, Nathan G, Laurent B, Jeanne B, Sylvie DF, Pierre M, Sylvie FE, Jean-Benoît Thambo, Bruno L, Pamela M, Lucile H, Sylvain R, Damien B. Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic. Circulation. 2020;142:429–436
[28] Mary Beth F Son, MDKevin Friedman, MD. COVID- 19: Multisystem inflammatory syndrome in children (MIS-C) clinical features, evaluation, and diagnosis UpToDate. 2021; May
[29.] Adam Ross, Hugh W. Shoff. Toxic Shock Syndrome In: StatPearls NCBI. 2020
[30] Centres for Disease Control and Prevention. Toxic Shock Syndrome (Other Than Streptococcal) (TSS) 2011 Case Definition. Available from URL: https://wwwn.cdc.gov/nndss/conditions/toxic-shock- syndrome-other-than-streptococcal/case- definition/2011/. Accessed June 28, 2021
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[32] Yilin F, Stephen T.A, Owen R.A, Shahzad IM. Novel case of an adult with toxic shock syndrome following COVID-19 infection NCBI. 2020; Jul 29. doi: 10.1016/j.ajoc.2020.100843
[33] Darmalaksana W. Metode Penelitian Kualitatif Studi Pustaka dan Studi Lapangan. Pre-print Digit Libr UIN Sunan Gunung Djati Bandung [Internet]. 2020;1–6. Available from:
http://digilib.uinsgd.ac.id/32855/1/Metode Penelitian Kualitatif.pdf
[34] Rahman I. Pencarian Informasi Skripsi pada Pustaka Fakultas Ilmu Komputer Universitas Lancang Kuning. J Teknol Inf dan Komun Digit Zo. 2016;7(1):66–74.
[35] Panigrahy N, Policarpio J, Ramanathan R. Multisystem inflammatory syndrome in children and SARS-CoV-2: A scoping review. J Pediatr Rehabil Med. 2020;13(3):301–16.
[36] Camila RC, Nicola Cotugno, Fabian S, Christian P, Donato A, Lucie R, Ziyang T, Sonia Z,Alessandra R, Giuseppe RP, Veronica S, Tessa C, Yenan B, Daniel E, Jun W, Alessandra M, Tadepally L, Andrea C, Alberto V, Paolo R, the CACTUS Study Team, Nils L, Paolo P, Petter B The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19 Cell. 2020;September 06 DOI
:https://doi.org/10.1016/j.cell.2020.09.016
[37] Kabeerdoss J, Pilania RK, Karkhele R, Kumar TS, Danda D, Singh S. Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int [Internet]. 2021;41(1):19–32. Available from: https://doi.org/10.1007/s00296-020-04749-4
[38] Rodriguez-Smith JJ, Verweyen EL, Clay GM, Esteban YM, de Loizaga SR, Baker EJ, et al. Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study. Lancet Rheumatol [Internet]. 2021;9913(21):1–12. Available from: http://dx.doi.org/10.1016/S2665-9913(21)00139-9
[39] Venkataraman A, Kumar NP, Hanna LE, Putlibai S, Karthick M, Rajamanikam A, et al. Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India. EBioMedicine [Internet]. 2021;66:103317. Available from: https://doi.org/10.1016/j.ebiom.2021.103317