Serum 25-hydroxy vitamin d deficiency against IL 17 acne vulgaris

Authors

  • Inggrid Limarda Tarumanagara University, Indonesia
  • Felly Moelyadi Tarumanagara University, Indonesia
  • Audina Aliansa Dimas Tara Tarumanagara University, Indonesia
  • Louis Rianto Tarumanagara University, Indonesia
  • Teddy Tjahyanto Tarumanagara University, Indonesia

DOI:

https://doi.org/10.35335/midwifery.v10i6.1063

Keywords:

Acne vulgaris, Deficiency, IL-17, Vitamin

Abstract

Vitamin D is essential to immune system function and influences many dermatological diseases, such as psoriasis and atopic dermatitis, a fat-soluble steroid hormone derivative sourced from food intake and synthesized in the skin through exposure to sunlight. Vitamin D deficiency is recognized as a global problem, with high cases in South and Southeast Asia. Acne vulgaris is a chronic inflammatory disease of the skin, specifically the pilosebaceous unit. Inflammation is a critical factor in the development of acne vulgaris. IL-17 is a proinflammatory cytokine that plays a central role in acne vulgaris inflammation. This study aims to obtain information regarding serum 25(OH)D deficiency for IL -17 acne vulgaris. The data collection method was through collecting data from articles related to serum 25-(OH)D deficiency against IL-17 acne vulgaris. The inclusion criteria involved original articles, case-control studies, and review papers on 25(OH)D, IL-17, and acne vulgaris. Vitamin D deficiency can lead to cosmogenesis and inflammatory exacerbations that characterize the acne vulgaris nodulocystic phenotype. The immune response in acne vulgaris is stimulated by the innate immune system via toll-like receptor 2 (TLR2) and adaptive immunity via Th1 lymphocytes. There is evidence that vitamin D inhibits TLR2 expression in monocytes and reduces proinflammatory cytokine production. The most common biomarker in inflammation is IL-17 which was significantly higher in acne vulgaris patients with vitamin D deficiency than in patients with normal vitamin D levels.

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References

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Published

2023-02-28

How to Cite

Limarda, I. (2023) “Serum 25-hydroxy vitamin d deficiency against IL 17 acne vulgaris”, Science Midwifery, 10(6), pp. 4814–4821. doi: 10.35335/midwifery.v10i6.1063.

Issue

Vol. 10 No. 6 (2023): February: Midwifery and Health Sciences

Section

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