Gallus domesticus egg-white gel accelerate wound healing after tooth extraction
##plugins.themes.academic_pro.article.sidebar##
Published
Apr 28, 2025
Download
Statistic
Downloads
Download data is not yet available.
##plugins.themes.academic_pro.article.main##
Abstract
Background: Tooth extraction is an action taken to prevent or treat the onset of a disease. However, there are still many complications after tooth extraction, such as a wound healing process that runs slowly and even causes excessive bleeding which can cause death. Gallus domesticus egg-white gel is a medicament that has growth factors that can help the wound healing process run smoothly. Purpose: To determine the number of inflammatory cells involved in the wound healing process after tooth extraction by the application Gallus domesticus egg-white gel. Methods: This research is an experimental laboratory in vivo involving 32 male Sprague dawley rats divided into 4 groups: treatment group (egg-white gel), positive control group (iodine glycerin), negative control group (gel base and saline). Each group will have the left mandibular central incisor extracted under ketamine. All samples were sacrificed on day 3 and 7 for histopathological examination. Results: The Kruskal-Wallis test showed a significance value of 0.00 (p <0.05) meaning that there was a significant difference in the number of inflammatory cells on the 3rd and 7th day. The significance value between treatment groups was 0.320 (p>0.05), which means there was no significant difference between groups. Conclusion: There was a decrease in the number of inflammatory cells in the wound healing process after tooth extraction by application of Gallus domesticus egg-white gel histologically to iodine glycerin on the 3rd and 7th day, but statistically there was no significant difference (p>0.05).
##plugins.themes.academic_pro.article.details##
How to Cite
Puspita, S., Putri, A. K. and Mahanani, E. S. (2025) “Gallus domesticus egg-white gel accelerate wound healing after tooth extraction ”, Science Midwifery, 13(1), pp. 336-344. doi: 10.35335/midwifery.v13i1.1913.
References
Abu Bakar Putri A. (2016). Analysis of albumin levels of the eels (anguilla marmorata and anguilla bicolor) and examination of its open wound healing activity on rabbit (oryctolagus cuniculus). Galen J Pharm J Pharm, 2(2):90-95.
Alhasyimi AA. (2018). Induksi re-epitelisasi pada proses penyembuhan luka gingiva oleh aplikasi topikal ekstrak daun sage (salvia officinalis l.) konsentrasi 50% (kajian in vivo pada tikus sprague dawley). B-Dent, J Kedokt Gigi Univ Baiturrahmah, 3(1):31-38.
Andritoiu CV, Andriescu CE, Danu M. (2021). Evaluation of the wound healing potential of some natural polymers on three experimental models. Pharmaceuticals, 14(5):1-17.
Ardana M, Aeyni V, Ibrahim A. Formulasi dan optimasi basis gel hpmc. (2015). J Trop Pharm Chem, 3(2):101-108.
Ariesanti Y, Rasad ISSP, Nimas M, Syabilla N. (2021). The effect of Persea americana Mill. seed extract on inflammatory cells and fibroblast formation in tooth extraction socket healing. Dent J (Majalah Kedokt Gigi), 54(4):190-194.
Astuti RD, Utami AR. (2021). Formulasi dan evaluasi sediaan gel ekstrak metanol kulit buah pisang raja (musa x paradisiaca aab) dengan variasi hpmc sebagai gelling agent. J Kesehat Pharmasi, 3(2):89-98.
A’ziza WA, Prihastuti CC, Rochmawati M, Rosyada AG, Amanda Putri ME. (2023). Aloe vera extract sheet and egg albumin (gallus domesticus) reduce the number of lymphocytes on gingival incision wound. J Kedokt Brawijaya, 32(4):211-216.
Bialik-Was K, Pluta K, Malina D, Barczewski M, Malarz K, Mrozek-Wilczkiewicz A. (2021). The effect of glycerin content in sodium alginate/poly(Vinyl alcohol)-based hydrogels for wound dressing application. Int J Mol Sci, 22(21).
da Silveira Teixeira D, de Figueiredo MAZ, Cherubini K, de Oliveira SD, Salum FG. (2019). The topical effect of chlorhexidine and povidone-iodine in the repair of oral wounds. A review. Stomatologija, 21(2):35-41.
Delpachitra, S., Sklavos, A., & Kumar, R. (2021). Principles of Dentoalveolar Extractions. John Wiley & Sons. 2021.
Eggermont JJ, Roberts LE. (2012). The neuroscience of tinnitus: understanding abnormal and normal auditory perception. Front Syst Neurosci, 6(JULY 2012):1-4.
Elrefay H, Ismaiel OA, Hassan WS, Shalaby A, Fouad A. (2022). RP-HPLC stability-indicating method for simultaneous determination of sodium valproate, methylparaben and propylparaben in oral solution. Acta Chromatogr, 34(2):203-209.
Evangeline, Supriadi D, Sunarya W. (2015). Perbedaan kompres nacl 0 , 9 % dengan kompres alkohol 70 % terhadap penurunan intensitas nyeri pada pasien flebitis. J Kedokt dan Kesehat, 2(3):245-251.
Ferdina R, Busman B, Putri RA. (2022). Penggunaan obat kumur povidone iodine sebagai tindakan pra-prosedural untuk mengurangi risiko penularan covid 19. Menara Ilmu, 16(2):77-83.
Gonzalez ACDO, Andrade ZDA, Costa TF, Medrado ARAP. (2016). Wound healing - a literature review. An Bras Dermatol. 91(5):614-620.
Guo S, DiPietro LA. (2010). Critical review in oral biology & medicine: Factors affecting wound healing. J Dent Res, 89(3):219-229.
Gupta S, Shinde S, Shinde RK. (2022). Topical management of wound: a narrative review of cadexomer iodine ointment versus povidone iodine ointment. Cureus, 14(4): 10-11.
Hendriati L, Hamid IS, Widodo T, Wandasari C, Risata PM. (2018). Effect of egg white gel againts burn healing on white rat (rattus novergicus). J Ilmu Kefarmasian Indones, 16(2):231.
Huynh NCN, Everts V, Leethanakul C, Pavasant P, Ampornaramveth RS. (2016). rinsing with saline promotes human gingival fibroblast wound healing in vitro. PLoS One, 11(7):1-13.
Jahani S, Ashrafizadeh H, Babai K, Siahpoosh A, Cheraghian B. (2019). Effect of ointment-based egg white on healing of second- degree wound in burn patients: a triple-blind randomized clinical trial study. Avicenna J phytomedicine, 9(3):260-270.
Kartiwa RA, Sovani I, Enus S, Boediono A, Miraprahesti RN. (2016). Albumin Telur sebagai lem pada operasi cangkok konjungtiva. Maj Kedokt Bandung, 48(4):241-248.
King`ori AM. Uses of Poultry Eggs: Egg albumen and egg yolk. (2012). Res J Poult Sci, 5(2):9-13.
Kusumaningrum HD, Nasution S, Kusumaningtyas E, Faridah DN. Lisozim dari putih telur ayam sebagai agen antibakterial. Indones Bull Anim Vet Sci. 2019;28(4):175.
Landén NX, Li D, Ståhle M. (2016). Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci, 73(20):3861-3885.
Mehrota D. Fundamentals of Oral and Maxillofacial Surgery. Published online 2020:387, 396, 402.
Ningsih JR, Haniastuti T, Handajani J. (2019). Re-epitelisasi luka soket pasca pencabutan gigi setelah pemberian gel getah pisang raja (Musa sapientum L) kajian histologis pada marmut (Cavia cobaya). JIKG (Jurnal Ilmu Kedokt Gigi), 2(1): 1-10.
Pranskunas M, Galindo-Moreno P, Padial-Molina M. (2019). Extraction socket preservation using growth factors and stem cells: a systematic review. J Oral Maxillofac Res, 10(3):1-11.
Primadina N, Basori A, Perdanakusuma DS. (2019). Proses penyembuhan luka ditinjau dari aspek mekanisme seluler dan molekuler. Qanun Med - Med J Fac Med Muhammadiyah Surabaya, 3(1):31.
Purnama H, Sriwidodo, Ratnawulan S. (2017). Review sistematik: proses penyembuhan dan perawatan luka. Farmaka, 15(2):251-256.
Sa’diyah JS, Septiana DA, Farih NN, Ningsih JR. (2020). Effect of 5% binahong (Anredera cordifolia) leaf extract in increasing the osteoblast amount at the tooth extraction wound healing process of Wistar rat.. J Kedokt Gigi Univ Padjadjaran, 32(1):9. doi:10.24198/jkg.v32i1.26885
Sakerebau S juleli. (2020). Uji efektivitas putih telur ayam kampung (gallus domesticus) terhadap penyembuhan luka bakar derajat ii pada mencit (mus musculus). J Ilmu Kesehat Indones, 1(2):185-192.
Siregar LHRM, Hariaji I. (2021). Efek Salep campuran biji kelengkeng (dimocarpus longan lour), minyak zaitun dan lilin lebah terhadap penyembuhan luka bakar pada tikus putih jantan galur wistar. J Ilm Simantek, 5(3):32-40.
Stout EI, McKessor A. (2012). Glycerin-based hydrogel for infection control. Adv Wound Care, 1(1):48-51.
Widyaningsih W, Yuliani S, Wulandari A, Salsabila R. (2021). Incision wound healing activity of free-range chicken (Gallus domesticus) egg white gel in mice. Pharmaciana, 2021;11(3):321.
Alhasyimi AA. (2018). Induksi re-epitelisasi pada proses penyembuhan luka gingiva oleh aplikasi topikal ekstrak daun sage (salvia officinalis l.) konsentrasi 50% (kajian in vivo pada tikus sprague dawley). B-Dent, J Kedokt Gigi Univ Baiturrahmah, 3(1):31-38.
Andritoiu CV, Andriescu CE, Danu M. (2021). Evaluation of the wound healing potential of some natural polymers on three experimental models. Pharmaceuticals, 14(5):1-17.
Ardana M, Aeyni V, Ibrahim A. Formulasi dan optimasi basis gel hpmc. (2015). J Trop Pharm Chem, 3(2):101-108.
Ariesanti Y, Rasad ISSP, Nimas M, Syabilla N. (2021). The effect of Persea americana Mill. seed extract on inflammatory cells and fibroblast formation in tooth extraction socket healing. Dent J (Majalah Kedokt Gigi), 54(4):190-194.
Astuti RD, Utami AR. (2021). Formulasi dan evaluasi sediaan gel ekstrak metanol kulit buah pisang raja (musa x paradisiaca aab) dengan variasi hpmc sebagai gelling agent. J Kesehat Pharmasi, 3(2):89-98.
A’ziza WA, Prihastuti CC, Rochmawati M, Rosyada AG, Amanda Putri ME. (2023). Aloe vera extract sheet and egg albumin (gallus domesticus) reduce the number of lymphocytes on gingival incision wound. J Kedokt Brawijaya, 32(4):211-216.
Bialik-Was K, Pluta K, Malina D, Barczewski M, Malarz K, Mrozek-Wilczkiewicz A. (2021). The effect of glycerin content in sodium alginate/poly(Vinyl alcohol)-based hydrogels for wound dressing application. Int J Mol Sci, 22(21).
da Silveira Teixeira D, de Figueiredo MAZ, Cherubini K, de Oliveira SD, Salum FG. (2019). The topical effect of chlorhexidine and povidone-iodine in the repair of oral wounds. A review. Stomatologija, 21(2):35-41.
Delpachitra, S., Sklavos, A., & Kumar, R. (2021). Principles of Dentoalveolar Extractions. John Wiley & Sons. 2021.
Eggermont JJ, Roberts LE. (2012). The neuroscience of tinnitus: understanding abnormal and normal auditory perception. Front Syst Neurosci, 6(JULY 2012):1-4.
Elrefay H, Ismaiel OA, Hassan WS, Shalaby A, Fouad A. (2022). RP-HPLC stability-indicating method for simultaneous determination of sodium valproate, methylparaben and propylparaben in oral solution. Acta Chromatogr, 34(2):203-209.
Evangeline, Supriadi D, Sunarya W. (2015). Perbedaan kompres nacl 0 , 9 % dengan kompres alkohol 70 % terhadap penurunan intensitas nyeri pada pasien flebitis. J Kedokt dan Kesehat, 2(3):245-251.
Ferdina R, Busman B, Putri RA. (2022). Penggunaan obat kumur povidone iodine sebagai tindakan pra-prosedural untuk mengurangi risiko penularan covid 19. Menara Ilmu, 16(2):77-83.
Gonzalez ACDO, Andrade ZDA, Costa TF, Medrado ARAP. (2016). Wound healing - a literature review. An Bras Dermatol. 91(5):614-620.
Guo S, DiPietro LA. (2010). Critical review in oral biology & medicine: Factors affecting wound healing. J Dent Res, 89(3):219-229.
Gupta S, Shinde S, Shinde RK. (2022). Topical management of wound: a narrative review of cadexomer iodine ointment versus povidone iodine ointment. Cureus, 14(4): 10-11.
Hendriati L, Hamid IS, Widodo T, Wandasari C, Risata PM. (2018). Effect of egg white gel againts burn healing on white rat (rattus novergicus). J Ilmu Kefarmasian Indones, 16(2):231.
Huynh NCN, Everts V, Leethanakul C, Pavasant P, Ampornaramveth RS. (2016). rinsing with saline promotes human gingival fibroblast wound healing in vitro. PLoS One, 11(7):1-13.
Jahani S, Ashrafizadeh H, Babai K, Siahpoosh A, Cheraghian B. (2019). Effect of ointment-based egg white on healing of second- degree wound in burn patients: a triple-blind randomized clinical trial study. Avicenna J phytomedicine, 9(3):260-270.
Kartiwa RA, Sovani I, Enus S, Boediono A, Miraprahesti RN. (2016). Albumin Telur sebagai lem pada operasi cangkok konjungtiva. Maj Kedokt Bandung, 48(4):241-248.
King`ori AM. Uses of Poultry Eggs: Egg albumen and egg yolk. (2012). Res J Poult Sci, 5(2):9-13.
Kusumaningrum HD, Nasution S, Kusumaningtyas E, Faridah DN. Lisozim dari putih telur ayam sebagai agen antibakterial. Indones Bull Anim Vet Sci. 2019;28(4):175.
Landén NX, Li D, Ståhle M. (2016). Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci, 73(20):3861-3885.
Mehrota D. Fundamentals of Oral and Maxillofacial Surgery. Published online 2020:387, 396, 402.
Ningsih JR, Haniastuti T, Handajani J. (2019). Re-epitelisasi luka soket pasca pencabutan gigi setelah pemberian gel getah pisang raja (Musa sapientum L) kajian histologis pada marmut (Cavia cobaya). JIKG (Jurnal Ilmu Kedokt Gigi), 2(1): 1-10.
Pranskunas M, Galindo-Moreno P, Padial-Molina M. (2019). Extraction socket preservation using growth factors and stem cells: a systematic review. J Oral Maxillofac Res, 10(3):1-11.
Primadina N, Basori A, Perdanakusuma DS. (2019). Proses penyembuhan luka ditinjau dari aspek mekanisme seluler dan molekuler. Qanun Med - Med J Fac Med Muhammadiyah Surabaya, 3(1):31.
Purnama H, Sriwidodo, Ratnawulan S. (2017). Review sistematik: proses penyembuhan dan perawatan luka. Farmaka, 15(2):251-256.
Sa’diyah JS, Septiana DA, Farih NN, Ningsih JR. (2020). Effect of 5% binahong (Anredera cordifolia) leaf extract in increasing the osteoblast amount at the tooth extraction wound healing process of Wistar rat.. J Kedokt Gigi Univ Padjadjaran, 32(1):9. doi:10.24198/jkg.v32i1.26885
Sakerebau S juleli. (2020). Uji efektivitas putih telur ayam kampung (gallus domesticus) terhadap penyembuhan luka bakar derajat ii pada mencit (mus musculus). J Ilmu Kesehat Indones, 1(2):185-192.
Siregar LHRM, Hariaji I. (2021). Efek Salep campuran biji kelengkeng (dimocarpus longan lour), minyak zaitun dan lilin lebah terhadap penyembuhan luka bakar pada tikus putih jantan galur wistar. J Ilm Simantek, 5(3):32-40.
Stout EI, McKessor A. (2012). Glycerin-based hydrogel for infection control. Adv Wound Care, 1(1):48-51.
Widyaningsih W, Yuliani S, Wulandari A, Salsabila R. (2021). Incision wound healing activity of free-range chicken (Gallus domesticus) egg white gel in mice. Pharmaciana, 2021;11(3):321.