Comparison of the effectiveness of colloidal oatmeal 1% with petrolatum 100% to repair the skin bars in psoriasis vulgaris: A study of trans-epidermal water loss
DOI:
https://doi.org/10.35335/midwifery.v13i4.2118Keywords:
Colloidal Oatmeal 1%, Petrolatum 100%, Psoriasis Vulgaris, Trans-Epidermal Water LossAbstract
The purpose of this study was to compare the effectiveness of 1% colloidal oatmeal with 100% petrolatum in improving the skin barrier in patients with psoriasis vulgaris. This research method is a randomized, single-blind, pre and posttest design controlled trial involving patients with mild/moderate/severe psoriasis vulgaris at DR. Kariadi Hospital Semarang, Indonesia. The subjects of the study were divided into 2 groups, namely 1% colloidal oatmeal and 100% petrolatum. Evaluation was carried out by comparing the TEWL values between day 0 and day 28. The analysis was carried out using independent T-tests, Mann Whitney, and Wilcoxon. The results were significant if p<0.05 Results Topical administration of 1% colloidal oatmeal or 100% petrolatum could lower the TEWL value in each study group (p<0.001; p=0.006 respectively). ÃŽâ€ÂTEWL evaluation showed a significantly greater decrease in TEWL in the 1% colloidal oatmeal group (p=0.003). No complaints during use were reported in the 1% colloidal oatmeal group. Conclusion: Topical application of 1% colloidal oatmeal is more effective than 100% petrolatum as a moisturizer in improving the skin barrier in patients with psoriasis vulgaris without complaints.
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Alhammad, I. M., Aseri, A. M., Alqahtani, S. A. M., Alshaebi, M. F., Alqahtani, S. A., Alzahrani, R. A., … Jad, A. Y. (2021). A review on updates in management and treatment of psoriasis. Archives of Pharmacy Practice, 12(1–2021), 74–78.
Armstrong, A. W., & Read, C. (2020). Pathophysiology, clinical presentation, and treatment of psoriasis: a review. Jama, 323(19), 1945–1960.
Becker, L. C., Bergfeld, W. F., Belsito, D. V, Hill, R. A., Klaassen, C. D., Liebler, D. C., … Snyder, P. W. (2019). Safety assessment of Avena sativa (Oat)-derived ingredients as used in cosmetics. International Journal of Toxicology, 38(3_suppl), 23S-47S.
Catherine Mack Correa, M., & Nebus, J. (2012). Management of patients with atopic dermatitis: the role of emollient therapy. Dermatology Research and Practice, 2012(1), 836931.
Criquet, M., Roure, R., Dayan, L., Nollent, V., & Bertin, C. (2012). Safety and efficacy of personal care products containing colloidal oatmeal. Clinical, Cosmetic and Investigational Dermatology, 183–193.
Dewi, D., & IG, I. (2018). Insiden dan profil psoriasis di poliklinik kulit dan kelamin Rumah Sakit Umum Pusat Sanglah Denpasar periode Januari 2012 sampai Desember 2014. E-Jurnal Medika Udayana, 7(9), 1–7.
Dhabale, A., & Nagpure, S. (2022). Types of psoriasis and their effects on the immune system. Cureus, 14(9).
Gerreth, P., Maciejczyk, M., Zalewska, A., Gerreth, K., & Hojan, K. (2020). Comprehensive evaluation of the oral health status, salivary gland function, and oxidative stress in the saliva of patients with subacute phase of stroke: a case-control study. Journal of Clinical Medicine, 9(7), 2252.
Goldsmith, L. A., Fitzpatrick, T. B., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D. J., & Wolff, K. (2012). Fitzpatrick’s dermatology in general medicine. (No Title).
Guillet, C., Seeli, C., Nina, M., Maul, L. V., & Maul, J.-T. (2022). The impact of gender and sex in psoriasis: What to be aware of when treating women with psoriasis. International Journal of Women’s Dermatology, 8(2), e010.
Limaye, S., & Weightman, W. (1997). Effect of an ointment containing boric acid, zinc oxide, starch and petrolatum on psoriasis. Australasian Journal of Dermatology, 38(4), 185–186.
Lin, T.-K., Zhong, L., & Santiago, J. L. (2018). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
Lodén, M. (1997). Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. Contact Dermatitis, 36(5), 256–260.
Luger, T., Seite, S., Humbert, P., Krutmann, J., Triller, R., & Dréno, B. (2014). Recommendations for adjunctive basic skin care in patients with psoriasis. European Journal of Dermatology, 24(2), 194–200.
Matheson, J. D., Clayton, J., & Muller, M. J. (2001). The reduction of itch during burn wound healing. The Journal of Burn Care & Rehabilitation, 22(1), 76–81.
Maul, J.-T., Anzengruber, F., Conrad, C., Cozzio, A., Häusermann, P., Jalili, A., … Mainetti, C. (2021). Topical treatment of psoriasis vulgaris: the Swiss treatment pathway. Dermatology, 237(2), 166–178.
Mawazi, S. M., Ann, J., Othman, N., Khan, J., Alolayan, S. O., Al thagfan, S. S., & Kaleemullah, M. (2022). A review of moisturizers; history, preparation, characterization and applications. Cosmetics, 9(3), 61.
Michelle Garay, M. (2016). Colloidal oatmeal (Avena Sativa) improves skin barrier through multi-therapy activity. J Drugs Dermatol, 15(6), 684–690.
Montero-Vilchez, T., Segura-Fernández-Nogueras, M.-V., Pérez-RodrÃÂÂguez, I., Soler-Gongora, M., Martinez-Lopez, A., Fernández-González, A., … Arias-Santiago, S. (2021). Skin barrier function in psoriasis and atopic dermatitis: transepidermal water loss and temperature as useful tools to assess disease severity. Journal of Clinical Medicine, 10(2), 359.
Naufal, A., Damayanti, K. E. H., & Hidayati, A. N. (2021). Risk factor profile and quality of life of psoriasis vulgaris. Periodical of Dermatology and Venereology, 33(2), 129–134.
Nicolescu, A. C., Bucur, Ștefana, Giurcăneanu, C., Gheucă-Solovăstru, L., Constantin, T., Furtunescu, F., … Constantin, M. M. (2021). Prevalence and characteristics of psoriasis in Romaniaâ€â€ÂFirst study in overall population. Journal of Personalized Medicine, 11(6), 523.
Sobhan, M., Hojati, M., Vafaie, S.-Y., Ahmadimoghaddam, D., Mohammadi, Y., & Mehrpooya, M. (2020). The efficacy of colloidal oatmeal cream 1% as add-on therapy in the management of chronic irritant hand eczema: A double-blind study. Clinical, Cosmetic and Investigational Dermatology, 241–251.
Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2018). Natural oils for skin-barrier repair: Ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 19(1), 103–117.
Vie, K., Cours-Darne, S., Vienne, M. P., Boyer, F., Fabre, B., & Dupuy, P. (2002). Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model. Skin Pharmacology and Physiology, 15(2), 120–124.
Zhu, J., Wang, Y.-F., Song, S.-S., Wu, L.-L., Chen, Y., Li, X.-Y., & Ju, M. (2023). Alleviating skin barrier disruption, skin inflammation, and pruritus: A moisturizing spray containing β-glucan and panthenol. International Journal of Dermatology and Venereology, 6(01), 1–8.
