The potential of trigona honey as a hemoglobin booster and immunomodulator in pregnant women with iron deficiency anemia
DOI:
https://doi.org/10.35335/midwifery.v13i6.2151Keywords:
Anemia, Hemoglobin, Pregnancy, Trigona HoneyAbstract
Background: Iron deficiency anemia in pregnancy constitutes a significant public health issue, as it elevates the likelihood of adverse pregnancy outcomes, including pregnancy complications. In West Lombok, the prevalence of anemia among pregnant women was reported to reach 18.6%. Despite government efforts through iron supplementation programs, challenges remain, including low adherence and limited bioavailability. Therefore, alternative natural supplements are needed. Trigona honey contains micronutrients and bioactive compounds with hematopoietic and immunomodulatory properties, making it a potential natural agent to improve hemoglobin levels and immune function. Objective: To examine the impact of Trigona honey supplementation on the hemoglobin levels of pregnant women with IDA. Methods: This true experimental research employed a pretest–posttest control group design and was carried out within the service area of the Jembatan Kembar Community Health Center. Thirty pregnant women were recruited using purposive sampling and divided into two groups: intervention (Trigona honey + iron) and control (iron only), each with 15 participants. Data were collected using questionnaires and Touch GCHB tests to measure hemoglobin levels. Statistical analyses were performed using paired and independent t-tests with a significance thresholdof p < 0.05. Results: Hemoglobin levels increased significantly in both groups; however, the intervention group demonstrated a more substantial improvement (mean = 2.89; p = 0.000) compared to the control group (mean = 0.65; p = 0.010). Conclusion: Trigona honey significantly enhanced hemoglobin levels compared to iron supplementation alone. It may serve as a promising non-pharmacological complementary therapy for preventing and managing iron deficiency anemia in pregnant women.
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Afrida, Baiq Ricca, and Ni Putu Aryani. 2022. “Hubungan Stunting Terhadap Perkembangan Motorik Balita.” Jurnal Ilmiah Universitas Batanghari Jambi 22(1): 459–63. doi:10.33087/jiubj.v22i1.1846.
Agus, Ali, Universitas Gadjah Mada, Agussalim Agussalim, Universitas Gadjah Mada, Nurliyani Nurliyani, Universitas Gadjah Mada, Nafiatul Umami, and Universitas Gadjah Mada. 2019. “Evaluation of Antioxidant Activity, Phenolic, Flavonoid and Vitamin C Content of Several Honeys Produced by the Indonesian Stingless Bee: Tetragonula Laeviceps Ali Agus, Agussalim, Nurliyani, Nafiatul Umami and I Gede Suparta Budisatria.” (October).
Ahmady, Ahmady, Zulhaini Sartika A Pulungan, and Edi Purnomo. 2021a. “Peningkatan Kadar Hemoglobin Ibu Hamil Anemia Dengan Kombinasi Pemberian Tablet Fe Dan Madu.” Jurnal Kesehatan 12(2): 242–47.
Ahmady, Ahmady, Zulhaini Sartika A Pulungan, and Edi Purnomo. 2021b. “Peningkatan Kadar Hemoglobin Ibu Hamil Anemia Dengan Kombinasi Pemberian Tablet Fe Dan Madu.” Jurnal Kesehatan 12(2): 242–47.
Allen, Lindsay H. 2000. “Anemia and Iron Deficiency: Effects on Pregnancy Outcome.” The American journal of clinical nutrition 71(5): 1280S-1284S.
Ananda Nuristigfarin1, Ica Maulina Rifkiyatul Islami2. 2022. “HUBUNGAN KEPATUHAN KONSUMSI TABLET FE DENGAN KEJADIAN ANEMIA PADA IBU HAMIL.” 1(1): 1252–65. doi:10.58344/jii.v1i12.746.
Angrainy, Rizka. 2017. “Hubungan Pengetahuan Dengan Sikap Ibu Hamil Dalam Pencegahan Anemia Pada Kehamilan Di Puskesmas Rumbai Bukit Tahun 2016.” Jurnal Endurance 2(1): 62–67.
Asrida, A, Astuti Astuti, Leli Leli, and Rahmiyani Saad. 2022. “Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia.” Journal of Asian Multicultural Research for Medical and Health Science Study 3(3): 25–31.
Baker, Robert D, Frank R Greer, and Committee on Nutrition. 2010. “Diagnosis and Prevention of Iron Deficiency and Iron-Deficiency Anemia in Infants and Young Children (0–3 Years of Age).” Pediatrics 126(5): 1040–50.
Biluca, Fabíola Carina, Francieli Braghini, Luciano Valdemiro Gonzaga, Ana Carolina Oliveira Costa, and Roseane Fett. 2016. “Physicochemical Profiles, Minerals and Bioactive Compounds of Stingless Bee Honey (Meliponinae).” Journal of Food Composition and Analysis 50: 61–69.
Dahliansyah, Dahliansyah, and Yanuarti Petrika. 2020. “Pemberian Madu Trigona Sp.(Kelulut) Dan Sari Jeruk Siam Sambas Terhadap Kadar Hemoglobin Darah (Hb) Ibu Hamil.” Jurnal Surya Medika (JSM) 6(1): 157–62.
Dikes Lombok Barat. 2022. Profil Kesehatan Kabupaten Lombok Barat.
DikesProvinsiNTB. 2021. Profil Kesehatan Provinsi Nusa Tenggara Barat. Mataram.
Ekström, E C, Festo P Kavishe, Jean-Pierre Habicht, Edward A Frongillo Jr, Kathleen M Rasmussen, and Lunna Hemed. 1996. “Adherence to Iron Supplementation during Pregnancy in Tanzania: Determinants and Hematologic Consequences.” The American journal of clinical nutrition 64(3): 368–74.
Fajari, Nanang Miftah, Sp PD, FINASIM K-EMD, Agung Pranoto, Sp PD, David S Perdanakusuma, Sp BPRE, et al. Madu Kelulut: Harta Karun Bagi Dunia Kesehatan. Jakad Media Publishing.
Febriani, A Y U, and S T Aisyah Sijid. 2021. “Review: Anemia Defisiensi Besi.” (November): 137–42.
Idyawati, Susilia, Baiq Ricca Afrida, Ni Putu Aryani, and Sri Hawari Jannati. 2024. “The Relationship of Age and Gravida Status with The Incident of Anemia in Pregnant Women in Tanjung Karang Community Health Center.” Jurnal Ilmiah Kebidanan (The Journal Of Midwifery) 12(1): 44–50. doi:10.33992/jik.v12i1.3222.
Kemenkes RI. 2021. “Profil Kesehatan Indonesia.”
KemenkesRI. 2021. “Profil Kesehatan Indonesia.”
Kursiah Warti Ningsih, Roza Asnel, Ahmat Saputra, Mailiza Cahyani. 2024. “PERILAKU IBU HAMIL DALAM MENGKONSUMSI TABLET FE TERHADAP KEJADIAN ANEMIA PENDAHULUAN Menurut World Health Organization (WHO) Pada Tahun 2019, Prevalensi Anemia Pada Ibu Hamil Di Dunia Sebanyak 36, 5 % Dengan Prevalensi Terbesar Terdapat Di Negara Berk.” 13: 63–75.
Liana, Neny, Ratna Wulandari, and Salfia Darmi. 2023. “Hubungan Pola Makan, Riwayat Kehamilan Dan Kepatuhan Konsumsi Tablet Fe Terhadap Kejadian Anemia Pada Ibu Hamil Trimester Iii Di Rumah Sakit Medika Krakatau Kota Cilegon Tahun 2022.” SENTRI: Jurnal Riset Ilmiah 2(4): 1029–42.
Lynch, Sean R. 2005. “The Impact of Iron Fortification on Nutritional Anaemia.” Best practice & research clinical haematology 18(2): 333–46.
Manikam, Nurul Ratna Mutu. 2021. “Known Facts: Iron Deficiency in Indonesia.” World Nutrition Journal 5(S1): 1–9.
Manuaba, Ida Bagus Gde. 1998. “Ilmu Kebidanan, Penyakit Kandungan & Keluarga Berencana Untuk Pendidikan Bidan.” In Egc.
Maternity, Dainty, and Yulina Wati. 2024. “KONSUMSI MADU DAN TABLET FE TERHADAP KENAIKAN KADAR HB IBU HAMIL.” In Prosiding Polkesta Seminar Nasional, 35–44.
Munafiah, Durrotun, Eni Kusyati, and Nely Inayati. 2019. “Pemberian Tablet Fe Dan MAMA (Madu Kurma) Meningkatkan Kadar Hemoglobin Kehamilan Aterm Dalam Persiapan Persalinan.” In Prosiding Seminar Nasional Unimus,
Nurmayani, Winda, Elisa Oktaviani, and Dewi Nursukma Purqoti. 2021. “Edukasi Pada Ibu Hamil Untuk Mencegah Anemia.” 2(1): 69–74.
Oppenheimer, Stephen J. 2001. “Iron and Its Relation to Immunity and Infectious Disease.” The Journal of nutrition 131(2): 616S-635S.
Organization, World Health. 2012. “Guideline: Daily Iron and Folic Acid Supplementation in Pregnant Women.” In Guideline: Daily Iron and Folic Acid Supplementation in Pregnant Women, , 32.
Organization, World Health. 2024. Guideline on Haemoglobin Cutoffs to Define Anaemia in Individuals and Populations. World Health Organization.
Pavord, Sue, Bethan Myers, Susan Robinson, Shubha Allard, Jane Strong, Christina Oppenheimer, and British Committee for Standards in Haematology. 2012. “UK Guidelines on the Management of Iron Deficiency in Pregnancy.” British journal of haematology 156(5): 588–600.
Petrika, Dahliansyah* Yanuarti. 2013. “TERHADAP KADAR HEMOGLOBIN DARAH (Hb) IBU HAMIL Giving Honey Trigona Sp. (Kelulut) And Sari Orange Of Organic Size Of Blood Hemoglobin Content (Hb) Pregnant Mother.”
Di PKM, I I. 2022. “Hubungan Status Paritas Dan Pekerjaan Dengan Kejadian Anemia Pada Ibu Hamil Trimester II Di PKM Purwokerto Selatan, Kabupaten Banyumas.”
Puti Tika Rianti, Sukarni, Iis Tri Utami, Hellen Febriyanti. 2022. “Pengaruh Madu Terhadap Kadar Hemoglobin Pada Ibu Hamil.” Jurnal Maternitas Aisyah (JAMAN AISYAH) 159: 159–65.
RIANTI, PUTRI TIKA, Iis Tri Utami, and Hellen Febriyanti. 2022. “Pengaruh Madu Terhadap Kadar Hemoglobin Pada Ibu Hamil.” Jurnal Maternitas Aisyah (JAMAN AISYAH) 3(2): 159–65.
Rianti, Rianti, Fatmawati Fatmawati, and Suwarni Suwarni. 2022. “Tingkat Pengetahuan, Kepatuhan Konsumsi Tablet Tambah Darah Dan Asupan Zat Besi (Fe) Dengan Status Anemia Pada Remaja Putri Di SMKN 1 Molawe Kecamatan Molawe Kabupaten Konawe Utara.” Jurnal Gizi Ilmiah 9(2): 12–18.
Sari, Larasajeng Permata, and Siti Nur Djannah. 2020. “Kepatuhan Konsumsi Tablet Fe Pada Ibu Hamil: Compliance With Tablet Fe Consumption In Pregnant Women.” Quality: Jurnal Kesehatan 14(2): 113–18.
Scholl, Theresa O. 2005. “Iron Status during Pregnancy: Setting the Stage for Mother and Infant2–3.” The American journal of clinical nutrition 81(5): 1218S-1222S.
Simatupang, Melva, and Franciska Debora Simanjuntak. 2022. “Efektivitas Jus Jeruk, Tomat, Dan Madu Untuk Mengatasi Anemia Pada Ibu Hamil.” Jurnal Penelitian Kesehatan" SUARA FORIKES"(Journal of Health Research" Forikes Voice") 13(4): 913–19.
Sugiharti, Rosi Kurnia, and Etika Dewi Cahyaningrum. 2020. “The Correlation Between Family Income and Mom’s Education with Anemia.” In 1st International Conference on Community Health (ICCH 2019), Atlantis Press, 94–96.
Tang YM, Chen XZ, Li GR, Zhou RH, Ning H, Yan H. 2006. “Effects of Iron Deficiency Anemia on Immunity and Infectious Disease in Pregnant Women.” Wei Sheng Yan Jiu. 2006 Jan;35(1):79-81. Chinese. PMID: 16598942.
Tunçalp, Ozge, Juan Pablo Pena‐Rosas, Theresa Lawrie, Maurice Bucagu, Olufemi T Oladapo, Anayda Portela, and A Metin Gülmezoglu. 2017. “WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience—Going beyond Survival.” BJOG: an international journal of obstetrics and gynaecology 124(6): 860–62.
VanderMeulen, Heather, Elaine Herer, Chantal Armali, Amie Kron, Dimpy Modi, Anne McLeod, Michelle Sholzberg, Jeannie Callum, and Yulia Lin. 2021. “Iron Deficiency and Anemia in Pregnancy: A Health Equity Issue.” Journal of Obstetrics and Gynaecology Canada 43(5): 665.
Wibowo, Joko Wahyu, Minidian Fasitasari, and Siti Thomas Zulaikhah. 2021. “Effects of Propolis Extract Supplementation during Pregnancy on Stress Oxidative and Pregnancy Outcome: Levels of Malondialdehyde, 8-Oxo-2†2-Deoxogunosine, Maternal Body Weight, and Number of Fetuses.” Jurnal Kedokteran Brawijaya 31(3): 156–61.
Yanti, Dhiny Easter. 2016. “Hubungan Kepatuhan Konsumsi Tablet Fe Dengan Kejadian Anemia Pada Ibu Hamil Trimester III Di Puskesmas Bernung Kabupaten Pesawaran 2016.” Jurnal Dunia Kesmas 5(3).
Zhang, Jing, Quanhong Li, Ying Song, Liping Fang, Lei Huang, and Yu Sun. 2022. “Nutritional Factors for Anemia in Pregnancy: A Systematic Review with Meta-Analysis.” Frontiers in Public Health 10: 1041136.
