Review: Manufacturing Of Magnesium Oxide Nanoparticles As Antibacterial Agents


Asep Nandiyanto
Risti Ragadhita
Citra Nurhashiva
Tedi Kurniawan


The purpose of this article is to determine the most efficient synthesis method of magnesium oxide nanoparticles as an antimicrobial. The magnesium oxide synthesis method discussed in this study is complemented by the results of the study of the material sources, methods, advantages, and disadvantages of each method so that it can be a reference for choosing which method is more efficient in the synthesis of magnesium oxide. synthesis of magnesium oxide such as (1) synthesis of plant extracts,(2)) combustion, (3) sonochemical synthesis, (4) sol-gel synthesis, and (5) solid-state taken from the journal 2017-2020. This synthesis method resulted in the characterization of magnesium oxide nanoparticles which were analyzed using X-ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), Field Emission Scanning Electron Microscopy (FESEM). The results showed that there were advantages and disadvantages of each method of synthesis of magnesium oxide used. The most efficient method for synthesizing magnesium oxide as an antimicrobial is the sol-gel synthesis method. The sol-gel method uses readily available materials, has a relatively low cost, easy procedure to perform, and was found to be a light and efficient route for large-scale industrial production of fine magnesium oxide nanoparticles as antimicrobials.


How to Cite
Nandiyanto, A., Ragadhita, R., Nurhashiva, C. and Kurniawan, T. (2021) “Review: Manufacturing Of Magnesium Oxide Nanoparticles As Antibacterial Agents”, Science Midwifery, 10(1, October), pp. 41-54. Available at: (Accessed: 15October2021).


[1] Prasanth, R., Kumar, S. Dinesh, Jayalakshmi, A., Singaravelu, G., Govindaraju, K., & Kumar, V. Ganesh, “Green synthesis of magnesium oxide nanoparticles and their antibacterial activity,” Indian Journal of Geo Marine Sciences,vol. 48(08),pp. 1210-1215. 2019.
[2] Bhattacharya, P., Swain, S., Giri, L., & Neogi, S., “Fabrication of magnesium oxide nanoparticles by solvent alteration and their bactericidal applications,” Journal of Materials Chemistry B,vol. 7(26),pp. 4141-4152. 2019.
[3] Jeevanandam, J., Chan, Y. S., & Danquah, M. K., “Calcination‐dependent morphology transformation of sol‐gel‐synthesized MgO nanoparticles,” ChemistrySelect,vol. 2(32),pp. 10393-10404. 2017.
[4] Wong, C. W., San Chan, Y., Jeevanandam, J., Pal, K., Bechelany, M., Abd Elkodous, M., & El-Sayyad, G. S., “Response surface methodology optimization of mono-dispersed MgO nanoparticles fabricated by ultrasonic-assisted sol–gel method for outstanding antimicrobial and antibiofilm activities,” Journal of Cluster Science,vol. 31(2), pp. 367-389. 2020.
[5] Karthik, K., Dhanuskodi, S., Gobinath, C., Prabukumar, S., & Sivaramakrishnan, S., “Fabrication of MgO nanostructures and its efficient photocatalytic, antibacterial and anticancer performance,” Journal of Photochemistry and Photobiology B: Biology,vol. 190,pp. 8–20. 2019.
[6] Karthik, K., Dhanuskodi, S., Gobinath, C., Prabukumar, S., & Sivaramakrishnan, S., “Ultrasonic-assisted CdO–MgO nanocomposite for multifunctional applications,” Materials Technology,vol. 34(7),pp. 403–414. 2019.
[7] Pugazhendhi, A., Prabhu, R., Muruganantham, K., Shanmuganathan, R., & Natarajan, S., “Anticancer, antimicrobial and photocatalytic activities of green synthesized magnesium oxide nanoparticles (MgONPs) using aqueous extract of Sargassum wightii,” Journal of Photochemistry and Photobiology B: Biology,vol. 190,pp. 86–97. 2019.
[8] Karthik, K., Dhanuskodi, S., Kumar, S. P., Gobinath, C., & Sivaramakrishnan, S., “Microwave assisted green synthesis of MgO nanorods and their antibacterial and anti-breast cancer activities,” Materials Letters,vol. 206,pp. 217–220. 2017.
[9]Dobrucka, R., “Synthesis of MgO nanoparticles using Artemisia abrotanum herba extract and their antioxidant and photocatalytic properties,” Iranian Journal of Science and Technology,Transactions A: Science,vol. 42,pp. 547-555. 2018.
[10] Balakrishnan, G., Velavan, R., Batoo, K. M., & Raslan, E. H., “Microstructure, optical and photocatalytic properties of MgO nanoparticles,” Results in Physics,vol. 16,pp. 103013. 2020.
[11] Essien, E. R., Atasie, V. N., Okeafor, A. O., & Nwude, D. O., “Biogenic synthesis of magnesium oxide nanoparticles using Manihot esculenta (Crantz) leaf extract,” International Nano Letters, vol. 10,pp. 43-48. 2020.
[12] Yunita, F. E., Natasha, N. C., Sulistiyono, E., Rhamdani, A. R., Hadinata, A., & Yustanti, E., “Time and amplitude effect on nano magnesium oxide synthesis from bittern using sonochemical process,” IOP Conference Series: Materials Science and Engineering,vol. 858, pp. 012045. 2020.
[13] Taghavi Fardood, S., Ramazani, A., & Woo Joo, S., “Eco-friendly synthesis of magnesium oxide nanoparticles using arabic Gum,” Journal of Applied Chemical Research,vol. 12,pp. 8-15. 2018.
[14] Zhang, H., Hu, J., Xie, J., Wang, S., & Cao, Y., “A solid-state chemical method for synthesizing MgO nanoparticles with superior adsorption properties,” RSC advances,vol. 9,pp. 2011-2017. 2019.