Immunization is an effort to provide immunity to infants and children by introducing vaccines into the body to make antibodies to prevent certain diseases. There are 22.6 million children in the world who are not covered by routine immunization. More than 13% of Indonesian children have not received complete immunization for various reasons, whereas complete immunization can protect children from epidemics, disability and death. The percentage of measles immunization nationally is 82.1%, DPT/HB1 immunization is only 3.3%, the number of diphtheria cases is 78.4%, this achievement has not met the 90% target which is Indonesia's commitment to the regional scope. Not achieving the immunization target is caused by various things, one of which is lack of knowledge from mothers about immunization. This study aims to determine the knowledge of mothers about giving basic immunization to babies in the work area of the Sigumpar Health Center, Tobasa Regency. The type of research used is descriptive, the population in this study is mothers who have babies 0-12 months and the research sample is 31 people who are taken by doing accidental sampling. The results of this study indicate that the majority of mothers' knowledge is in good category (67.7%) about giving basic immunization to babies at the Sigumpar Health Center, Tobasa Regency. direct visits so as to increase visits and maternal compliance in providing immunizations to their children so as to prevent disease for the baby's body.
 World Health Organization. 10 facts on immunization. Diakses dari http://www.who.int/en/news-room/fact-sheets/detail/immunizationcoverage.
 Kemenkes. Pedoman Pencegahan dan Pengendalian COVID-19. Jakarta: Kemenkes RI. 2020.
 Kemenkes. Profil kesehatan Indonesia. Jakarta: Kemenkes RI. 2019
 Nirwana Loddo, Armanto Makmun, Zulfiyah Surdam, Nabila Said Amri. Hubungan Tingkat Pengetahuan Ibu Terhadap Pemberian Imunisasi Dasar Pada Bayi Di Wilayah Kerja Puskesmas Kassi. URL artikel: http://greenmedicaljournal.umi.ac.id/index.php/gmj. 2019
 Mulyani S, Nyimas N, and Abdul Haris. PENGETAHUAN IBU TENTANG KELENGKAPAN IMUNISASI DASAR PADA BAYI. https://doi.org/10.22437/jmj.v6i1.4820. Vol. 6 No. 1 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan. 2017.
 Silaen H. Pelaksanaan Rapid Test Antigen Covid-19 Kepada Generasi Muda Kota Medan dan Deli Serdang https://doi.org/10.32509/abdimoestopo.v4i02.1447. 2021.
 Yuliana E.. Analisis pengetahuan siswa tentang makanan yang sehat dan bergizi terhadap jajanan di sekolah.http://repository.ump.ac.id/4114/. 2017
 Kurniawan, Syamsul. Pendidikan Karakter: Konsepsi & Implementasinya secara Terpadu di Lingkungan Keluarga, Sekolah, Perguruan Tinggi, dan Masyarakat. Yogyakarta: Ar-Ruzz Media. 2017.
 PUSPITASARI. A. PENGETAHUAN IBU TENTANG IMUNISASI DASAR DI PUSKESMAS KOTAGEDE 1 YOGYAKARTA.PROGRAM STUDI KEBIDANAN (D-3) SEKOLAH TINGGI ILMU KESEHATAN JENDERAL ACHMAD YANI YOGYAKARTA. 2017.