Formula development and characterization of nanostructured lipid carriers (NLC) vitamin E acetate with solid lipids compritol and precirol
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Abstract
Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but its nature is very lipophilic (log p±12.2) and has the potential to degrade. To overcome the problems of permeability and stability, vitamin E acetate needs to be developed in Nanostructured Lipid Carrier (NLC), which is a nano delivery system based on solid lipids and liquid lipids stabilized by surfactants as a colloidal system. The formulation of vitamin E acetate into NLC was carried out using the heat homogenization method, then sonicated using a probe sonicator. The materials used were 2% vitamin E acetate, 2-6% Compritol® and Precirol® solid lipids, 1% Myritol®, and 1-3% Chremophore and Plantacare® surfactants. The NLC results were then characterized by measuring particle size, zeta potential, polydispersity index, entrapment efficiency, and morphology. The characterization results showed that NLC vitamin E acetate had a particle size of 280-375 nm, a zeta potential of -23 mV to -28 mV, a polydispersity index <0.5, an entrapment efficiency of 92-97%, and a spherical morphology. The results showed that Nanostructured Lipid Carrier vitamin E acetate gave good results.
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How to Cite
Salsabilla, S., Jafar, G. and Fatmawati, F. (2024) “Formula development and characterization of nanostructured lipid carriers (NLC) vitamin E acetate with solid lipids compritol and precirol”, Science Midwifery, 12(5), pp. 1715-1722. doi: 10.35335/midwifery.v12i5.1752.
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Chauhan, I., Yasir, M., Verma, M. & Singh, A. P. (2020). Nanostructured lipid carriers: A groundbreaking approach for transdermal drug delivery. Advanced Pharmaceutical Bulletin, 10(2), 150–165. https://doi.org/10.34172/apb.2020.021
Ferreira, K. C. B., Valle, A. B. C. D. S., Paes, C. Q., Tavares, G. D. & Pittella, F. (2021). Nanostructured lipid carriers for the formulation of topical anti-inflammatory nanomedicines based on natural substances. Pharmaceutics, 13(9). https://doi.org/10.3390/pharmaceutics13091454
Garg, N. K., Sharma, G., Singh, B., Nirbhavane, P., Tyagi, R. K., Shukla, R. & Katare, O. P. (2017). Quality by Design (QbD)-enabled development of aceclofenac loaded-nano structured lipid carriers (NLCs): An improved dermatokinetic profile for inflammatory disorder(s). International Journal of Pharmaceutics, 517(1–2), 413–431. https://doi.org/10.1016/j.ijpharm.2016.12.010
Jafar, G., Abdassah, M., Rusdiana, T. & Khairunisa, R. (2021). Development and characterization of precirol ato 88 base in nanostructured lipid carriers (Nlc) formulation with the probe sonication method. International Journal of Applied Pharmaceutics, 13(special issue 3), 43–46. https://doi.org/10.22159/IJAP.2021.V13S3.08
Jafar, G., Agustin, E. & Puryani, D. (2019). Pengembangan Formula Solid Lipid Nanoparticles (SLN) Hidrokortison Asetat. Jurnal Pharmascience, 6(1), 83. https://doi.org/10.20527/jps.v6i1.6080
Jafar, G., Salsabilla, S. & Santoso, R. (2022). Development and Characterization of Compritol Ato® Base in Nanostructured Lipid Carriers Formulation With the Probe Sonication Method. International Journal of Applied Pharmaceutics, 14(Special Issue 4), 64–66. https://doi.org/10.22159/ijap.2022.v14s4.PP04
Lasmiani, N. M. E. (2024). Penentuan Potensi Tabir Surya dan Nilai Sun Protection Factor (SPF) Sediaan Krim Ekstrak Etanol Bunga Kenanga (Cananga odorata (Lamk.) Hook.) dengan Metode Spektrofotometri Uv-Vis. Universitas Mahasaraswati Denpasar.
Latter, G., Grice, J. E., Mohammed, Y., Roberts, M. S. & Benson, H. A. E. (2019). Targeted topical delivery of retinoids in the management of acne vulgaris: Current formulations and novel delivery systems. Pharmaceutics, 11(10). https://doi.org/10.3390/pharmaceutics11100490
Lestari, W. (2022). Photoaging. Syiah Kuala University Press.
Morais, J. M. & Burgess, D. J. (2014). In vitro release testing methods for vitamin e nanoemulsions. International Journal of Pharmaceutics, 475(1), 393–400. https://doi.org/10.1016/j.ijpharm.2014.08.063
Müller, R. H., Alexiev, U., Sinambela, P. & Keck, C. M. (2016). Nanostructured Lipid Carriers (NLC): The Second Generation of Solid Lipid Nanoparticles.
Nasiri, F., Faghfouri, L. & Hamidi, M. (2020). Preparation, optimization, and in-vitro characterization of α-tocopherol-loaded solid lipid nanoparticles (SLNs). Drug Development and Industrial Pharmacy, 46(1), 159–171. https://doi.org/10.1080/03639045.2019.1711388
Novanda, N. A. (2024). PENGARUH PEMBERIAN GEL EKSTRAK BUAH TOMAT TERHADAP KADAR TRANSFORMING GROWTH FACTOR BETA (TGF-β) DAN INTERLEUKIN-10 (IL-10)(Studi Eksperimental Pada Mencit yang Terpapar UVB). Universitas Islam Sultan Agung Semarang.
Pratiwi, L., KM, M., Anggraini Ambarsari, S., KM, M., Annarahayu, L., Keb, S. T., KM, M., Nawangsari, H., ST, S. & Keb, M. (2024). Kesehatan Wanita Indonesia. CV Jejak (Jejak Publisher).
Rohmah, M., Raharjo, S., Hidayat, C. & Martien, R. (2019). Formulasi dan Stabilitas Nanostructured Lipid Carrier dari Campuran Fraksi Stearin dan Olein Minyak Kelapa Sawit. Jurnal Aplikasi Teknologi Pangan, 8(1), 23–30. https://doi.org/10.17728/jatp.3722
Sarkar, R., Arora, P. & Garg, Kv. (2013). Cosmeceuticals for hyperpigmentation: What is available? Journal of Cutaneous and Aesthetic Surgery, 6(1), 4. https://doi.org/10.4103/0974-2077.110089
Shettigar, P., Koland, M., Sindhoor, S. M. & Prabhu, A. (2021). Formulation and Evaluation of Clarithromycin Loaded Nanostructured Lipid Carriers for the Treatment of Acne. Journal of Pharmaceutical Research International, September, 26–38. https://doi.org/10.9734/jpri/2021/v33i40b32260
Silva, S., Ferreira, M., Oliveira, A. S., Magalhães, C., Sousa, M. E., Pinto, M., Sousa Lobo, J. M. & Almeida, I. F. (2019). Evolution of the use of antioxidants in anti-ageing cosmetics. International Journal of Cosmetic Science, 41(4), 378–386. https://doi.org/10.1111/ics.12551
Sirikhet, J., Chanmahasathien, W., Raiwa, A. & Kiattisin, K. (2021). Stability enhancement of lycopene in Citrullus lanatus extract via nanostructured lipid carriers. Food Science and Nutrition, 9(3), 1750–1760. https://doi.org/10.1002/fsn3.2156
Souto, E. B., Baldim, I., Oliveira, W. P., Rao, R., Yadav, N., Gama, F. M. & Mahant, S. (2020). Expert Opinion on Drug Delivery SLN and NLC for topical , dermal , and transdermal drug delivery. Expert Opinion on Drug Delivery, 00(00), 1–21. https://doi.org/10.1080/17425247.2020.1727883
Sri, Y. & Estuningsih. (2020). PERBANDINGAN APLIKASI TERAPI AKUPUNKTUR DENGAN SUSU FERMENTASI KEFIR UNTUK MENGHAMBAT PROSES PENUAAN DINI yang tidak mengikuti peraturan sesuai dengan terapi akupunktur dan atau minum kerfir sesuai yang sudah dijadwalkan ; dan wanita yang mempunyai penyak. Jurnal Kesehatan Kusuma Husada, 153–160.
Sriarumtias, F. F., Darijanto, S. T. & Damayanti, S. (2017). Formulasi Dan Uji Potensi Antioksidan Nanostructured Lipid Carrier (Nlc) Retinil Palmitat. Acta Pharmaceutica Indonesia, 42(1), 25–31. https://doi.org/10.5614/api.v42i1.4563
Tofani, R. P., Sumirtapura, Y. C. & Darijanto, S. T. (2016). Formulation, characterisation, and in vitro skin diffusion of nanostructured lipid carriers for deoxyarbutin compared to a nanoemulsion and conventional cream. Scientia Pharmaceutica, 84(4), 634–645. https://doi.org/10.3390/scipharm84040634
Winarni, N. (2023). PENGARUH SERUM EKSTRAK DAUN SUKUN (Artocarpus Altilis) TERHADAP KADAR TNF-α DAN SOD (Studi experimental pada marmut yang dipapar sinar UVB). Universitas Islam Sultan Agung Semarang.