Analysis of determinants of adherence to anti-tuberculosis drugs in tb patients during covid-19 at the public health center of Aceh Besar Regency
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Mar 26, 2024
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Abstract
The Covid-19 pandemic has had a significant impact on TB patients, particularly in terms of treatment and drug monitoring. During the pandemic in 2020, there were 350 cases of TB in Aceh Besar District. This study aimed to assess the compliance of TB patients during the Covid-19 period at the Aceh Besar District Health Center. A cross-sectional study design was employed, and data were collected from 118 TB patients from April to October 2020. The research was conducted in April 2022. Questionnaires were used for data collection, and bivariate and multivariate analyses were performed using the STATA 12 application program. The results of the multivariate analysis revealed that several risk factors, including Covid-19, history of illness, sources of information, age, knowledge, and trips to the health center, were associated with non-compliance in taking OAT medications. Efforts to increase awareness and educate the public about the risk factors of TB should continue, even during the Covid-19 pandemic. Building partnerships with former TB patients who have completed treatment and recovered can also help in promoting adherence to OAT medications among current TB patients.
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How to Cite
Amiruddin, A., Ichwansyah, F., Hermansyah, H., Maidar, M. and Abdullah, A. (2024) “Analysis of determinants of adherence to anti-tuberculosis drugs in tb patients during covid-19 at the public health center of Aceh Besar Regency”, Science Midwifery, 12(1), pp. 216-225. doi: 10.35335/midwifery.v12i1.1432.
References
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Amran, R., Abdulkadir, W., Farmasi, J., Olahraga dan Kesehatan, F., & Amwan Jurusan Farmasi Fakultas Olahraga dan Kesehatan, R. (2021). Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien Di Puskesmas Tombulilato Kabupaten Bone Bolango. Indonesian Journal of Pharmaceutical Education, 1(1), 57–66. https://doi.org/10.37311/IJPE.V1I1.10123
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Gebremariam, R. B., Wolde, M., & Beyene, A. (2021). Determinants of adherence to anti-TB treatment and associated factors among adult TB patients in Gondar city administration, Northwest, Ethiopia: based on health belief model perspective. Journal of Health, Population and Nutrition, 40(1), 1–10. https://doi.org/10.1186/S41043-021-00275-6/TABLES/3
Glaziou, P. (2021). Predicted impact of the COVID-19 pandemic on global tuberculosis deaths in 2020. MedRxiv, 2020.04.28.20079582. https://doi.org/10.1101/2020.04.28.20079582
Global Tuberculosis Report 2022. (n.d.). Retrieved March 7, 2024, from https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
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Hayati, S. M., Purba, J. M., & Siregar, C. T. (2022). Analysis of Factors Affecting Acceptance and Commitment Therapy (ACT) in Pulmonary TB Patients. Indonesian Journal of Global Health Research, 4(3), 573–580. https://doi.org/10.37287/IJGHR.V4I3.1253
Ima Afifa Himayati, A., & Matematika dan Ilmu Pengetahuan Alam, F. (2023). ANALISIS REGRESI LOGISTIK BINER PADA FAKTOR RESIKO KEJADIAN TUBERKULOSIS. Jurnal Matematika Sains Dan Teknologi, 24(1), 01–14. https://doi.org/10.33830/JMST.V24I1.4666.2023
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Manurung, R., & Manurung, R. D. (2023). The relationship between compliance in the treatment of pulmonary TB to lung function in Humbang Hasundutan district. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 8(2), 897–902. https://doi.org/10.30604/jika.v8i3.2058
Risk Factors Affecting Multi-Drug Resistant Tuberculosis in Surakarta and Ngawi, Indonesia | Journal of Epidemiology and Public Health. (n.d.). Retrieved December 15, 2023, from https://www.jepublichealth.com/index.php/jepublichealth/article/view/13
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Wulandari, D. H., Administrasi, D., & Kesehatan, K. (2018). Analisis Faktor-Faktor yang Berhubungan dengan Kepatuhan Pasien Tuberkulosis Paru Tahap Lanjutan Untuk Minum Obat di RS Rumah Sehat Terpadu Tahun 2015. Jurnal Administrasi Rumah Sakit Indonesia, 2(1). https://doi.org/10.7454/ARSI.V2I1.2186
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Adane, A. A., Alene, K. A., Koye, D. N., & Zeleke, B. M. (2013). Non-Adherence to Anti-Tuberculosis Treatment and Determinant Factors among Patients with Tuberculosis in Northwest Ethiopia. PLOS ONE, 8(11), e78791. https://doi.org/10.1371/JOURNAL.PONE.0078791
Aderita, N. I., Murti, B., & Suryani, N. (2016). Risk Factors Affecting Multi-Drug Resistant Tuberculosis in Surakarta and Ngawi, Indonesia. Journal of Epidemiology and Public Health, 1(2), 86–99. https://doi.org/10.26911/JEPUBLICHEALTH.2016.01.02.02
Agyeman, A. A., & Ofori-Asenso, R. (2017). Tuberculosis—an overview. Journal of Public Health and Emergency, 1, 7–7. https://doi.org/10.21037/JPHE.2016.12.08
Alipanah, N., Jarlsberg, L., Miller, C., Linh, N. N., Falzon, D., Jaramillo, E., & Nahid, P. (2018). Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies. PLoS Medicine, 15(7). https://doi.org/10.1371/JOURNAL.PMED.1002595
Amran, R., Abdulkadir, W., Farmasi, J., Olahraga dan Kesehatan, F., & Amwan Jurusan Farmasi Fakultas Olahraga dan Kesehatan, R. (2021). Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien Di Puskesmas Tombulilato Kabupaten Bone Bolango. Indonesian Journal of Pharmaceutical Education, 1(1), 57–66. https://doi.org/10.37311/IJPE.V1I1.10123
Bagchi, S., Ambe, G., & Sathiakumar, N. (2010). Determinants of Poor Adherence to Anti-Tuberculosis Treatment in Mumbai, India. International Journal of Preventive Medicine, 1(4), 223. /pmc/articles/PMC3075517/
Chakaya, J., Khan, M., Ntoumi, F., Aklillu, E., Fatima, R., Mwaba, P., Kapata, N., Mfinanga, S., Hasnain, S. E., Katoto, P. D. M. C., Bulabula, A. N. H., Sam-Agudu, N. A., Nachega, J. B., Tiberi, S., McHugh, T. D., Abubakar, I., & Zumla, A. (2021). Global Tuberculosis Report 2020 – Reflections on the Global TB burden, treatment and prevention efforts. International Journal of Infectious Diseases, 113, S7–S12. https://doi.org/10.1016/J.IJID.2021.02.107
Cilloni, L., Fu, H., Vesga, J. F., Dowdy, D., Pretorius, C., Ahmedov, S., Nair, S. A., Mosneaga, A., Masini, E., Sahu, S., & Arinaminpathy, N. (2020a). The potential impact of the COVID-19 pandemic on the tuberculosis epidemic a modelling analysis. EClinicalMedicine, 28, 100603. https://doi.org/10.1016/j.eclinm.2020.100603
Cilloni, L., Fu, H., Vesga, J. F., Dowdy, D., Pretorius, C., Ahmedov, S., Nair, S. A., Mosneaga, A., Masini, E., Sahu, S., & Arinaminpathy, N. (2020b). The potential impact of the COVID-19 pandemic on the tuberculosis epidemic a modelling analysis. EClinicalMedicine, 28, 100603. https://doi.org/10.1016/j.eclinm.2020.100603
Erawatyningsih, E., Subekti, H., Kesehatan Kabupaten Dompu, D., Tenggara Barat, N., Studi Ilmu Keperawatan, P., & Ugm, F. (2009). FAKTOR-FAKTOR YANG MEMPENGARUHI KETIDAKPATUHAN BEROBAT PADA PENDERITA TUBERKULOSIS PARU FACTORS AFFECTING INCOMPLIANCE WITH MEDICATION AMONG LUNG TUBERCULOSIS PATIENTS. Berita Kedokteran Masyarakat, 25(3).
Fitri, L. D. (2018). Kepatuhan Minum Obat pada Pasien Tuberkulosis Paru. Jurnal Ilmu Kesehatan Masyarakat, 7(01), 33–42. https://doi.org/10.33221/JIKM.V7I01.50
Fitria, E., Ramadhan, R., & Rosdiana, R. (2017). Karakteristik Penderita Tuberkulosis Paru di Puskesmas Rujukan Mikroskopis Kabupaten Aceh Besar. Sel Jurnal Penelitian Kesehatan, 4(1), 13–20. https://doi.org/10.22435/SEL.V4I1.1441
Fukunaga, R., Glaziou, P., Harris, J. B., Date, A., Floyd, K., & Kasaeva, T. (2021). Epidemiology of Tuberculosis and Progress Toward Meeting Global Targets — Worldwide, 2019. Morbidity and Mortality Weekly Report, 70(12), 427. https://doi.org/10.15585/MMWR.MM7012A4
Gebremariam, R. B., Wolde, M., & Beyene, A. (2021). Determinants of adherence to anti-TB treatment and associated factors among adult TB patients in Gondar city administration, Northwest, Ethiopia: based on health belief model perspective. Journal of Health, Population and Nutrition, 40(1), 1–10. https://doi.org/10.1186/S41043-021-00275-6/TABLES/3
Glaziou, P. (2021). Predicted impact of the COVID-19 pandemic on global tuberculosis deaths in 2020. MedRxiv, 2020.04.28.20079582. https://doi.org/10.1101/2020.04.28.20079582
Global Tuberculosis Report 2022. (n.d.). Retrieved March 7, 2024, from https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
Gupta, R. K., Lucas, S. B., Fielding, K. L., & Lawn, S. D. (2015). Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: A systematic review and meta-analysis. AIDS, 29(15), 1987–2002. https://doi.org/10.1097/QAD.0000000000000802
Hayati, S. M., Purba, J. M., & Siregar, C. T. (2022). Analysis of Factors Affecting Acceptance and Commitment Therapy (ACT) in Pulmonary TB Patients. Indonesian Journal of Global Health Research, 4(3), 573–580. https://doi.org/10.37287/IJGHR.V4I3.1253
Ima Afifa Himayati, A., & Matematika dan Ilmu Pengetahuan Alam, F. (2023). ANALISIS REGRESI LOGISTIK BINER PADA FAKTOR RESIKO KEJADIAN TUBERKULOSIS. Jurnal Matematika Sains Dan Teknologi, 24(1), 01–14. https://doi.org/10.33830/JMST.V24I1.4666.2023
Keperawatan, J., & Kemenkes Gorontalo, P. (2020). PENGETAHUAN PENDERITA TUBERKULOSIS PARU TERHADAP KEPATUHAN MINUM OBAT ANTI TUBERKULOSIS. Jambura Health and Sport Journal, 2(1), 12–18. https://doi.org/10.37311/JHSJ.V2I1.4560
Laporan Program Penanggulangan Tuberkulosis Tahun 2022 KEMENTERIAN KESEHATAN REPUBLIK INDONESIA TAHUN 2023. (n.d.).
MacNeil, A., Glaziou, P., Sismanidis, C., Maloney, S., & Floyd, K. (2019). Global Epidemiology of Tuberculosis and Progress Toward Achieving Global Targets — 2017. Morbidity and Mortality Weekly Report, 68(11), 263. https://doi.org/10.15585/MMWR.MM6811A3
Manurung, R., & Manurung, R. D. (2023). The relationship between compliance in the treatment of pulmonary TB to lung function in Humbang Hasundutan district. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 8(2), 897–902. https://doi.org/10.30604/jika.v8i3.2058
Risk Factors Affecting Multi-Drug Resistant Tuberculosis in Surakarta and Ngawi, Indonesia | Journal of Epidemiology and Public Health. (n.d.). Retrieved December 15, 2023, from https://www.jepublichealth.com/index.php/jepublichealth/article/view/13
Rusman, R., & K, S. B. (2019). Faktor yang Mempengaruhi Penderita TB Paru Terhadap Kepatuhan Minum Obat Anti Tuberkulosis di Puskesmas Jatisawit Indramayu. Afiasi : Jurnal Kesehatan Masyarakat, 4(1), 33–40. https://doi.org/10.31943/AFIASI.V4I1.10
Sanyaolu, A. (2019). Tuberculosis: A Review of Current Trends. Epidemiology International Journal, 3(2). https://doi.org/10.23880/EIJ-16000123
Tuberculosis. (n.d.). Retrieved December 15, 2023, from https://www.who.int/health-topics/tuberculosis#tab=tab_1
Tuberkulosis Paru Fase Lanjutan Kecamatan Umbulsari Jember, P. DI, Ismi Mientarini, E., Sudarmanto, Y., Hasan, M., & Kedokteran Universitas Jember Jl Kalimantan, F. (2018). HUBUNGAN PENGETAHUAN DAN SIKAP TERHADAP KEPATUHAN MINUM OBAT PASIEN TUBERKULOSIS PARU FASE LANJUTAN DI KECAMATAN UMBULSARI JEMBER. Jurnal Ilmu Kesehatan Masyarakat, 14(1), 11–18. https://doi.org/10.19184/IKESMA.V14I1.10401
Widyasrini, E. R., Probandari, A. N., & -, R. (2017). Factors Affecting the Success of Multi Drug Resistance (MDR-TB) Tuberculosis Treatment in Residential Surakarta. Journal of Epidemiology and Public Health, 2(1), 45–57. https://doi.org/10.26911/JEPUBLICHEALTH.2017.02.01.05
Wulandari, D. H., Administrasi, D., & Kesehatan, K. (2018). Analisis Faktor-Faktor yang Berhubungan dengan Kepatuhan Pasien Tuberkulosis Paru Tahap Lanjutan Untuk Minum Obat di RS Rumah Sehat Terpadu Tahun 2015. Jurnal Administrasi Rumah Sakit Indonesia, 2(1). https://doi.org/10.7454/ARSI.V2I1.2186
Yang, F.-F., Dengan, B., Pasien, K., Pengobatan, T., Paru, T., Puskesmas, D., Uki, U.-F., Samory, S., Yunalia, E. M., Perdana, I., Suharto, S., & Eureka Nurseskasatmata, S. (2022). Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Pasien Terhadap Pengobatan Tuberkulosis Paru Di Puskesmas Urei-Faisei (URFAS). Indonesian Health Science Journal, 2(1). https://doi.org/10.52298/IHSJ.V2I1.25